Cargando…
Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study
Preliminary data have shown that it is possible to attempt in vitro fertilization (IVF) treatment in fresh cycles without the use of a gonadotropin-releasing hormone (GnRH) antagonist or any other medication to prevent the luteinizing hormone (LH) surge during ovarian stimulation. To date, there is...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095010/ https://www.ncbi.nlm.nih.gov/pubmed/37048828 http://dx.doi.org/10.3390/jcm12072743 |
_version_ | 1785023978409033728 |
---|---|
author | Messinis, Ioannis E. Messini, Christina I. Papanikolaou, Evangelos G. Makrakis, Evangelos Loutradis, Dimitrios Christoforidis, Nikolaos Arkoulis, Theodosis Anifandis, Georgios Daponte, Alexandros Siristatidis, Charalampos |
author_facet | Messinis, Ioannis E. Messini, Christina I. Papanikolaou, Evangelos G. Makrakis, Evangelos Loutradis, Dimitrios Christoforidis, Nikolaos Arkoulis, Theodosis Anifandis, Georgios Daponte, Alexandros Siristatidis, Charalampos |
author_sort | Messinis, Ioannis E. |
collection | PubMed |
description | Preliminary data have shown that it is possible to attempt in vitro fertilization (IVF) treatment in fresh cycles without the use of a gonadotropin-releasing hormone (GnRH) antagonist or any other medication to prevent the luteinizing hormone (LH) surge during ovarian stimulation. To date, there is no information on this topic in the context of a prospective controlled trial. However, as prevention of the LH surge is an established procedure in fresh cycles, the question is whether such a study can be performed in frozen cycles. We aim to perform a pilot study in order to compare the efficacy of a protocol using FSH alone with that of a protocol using follicle-stimulating hormone (FSH) plus a GnRH antagonist for controlled ovarian hyperstimulation (COH) in cycles of elective freezing in the context of a donor/recipient program. This is a seven-center, two-arm prospective pilot cohort study conducted at the respective Assisted Reproductive Units in Greece. The hypothesis to be tested is that an ovarian stimulation protocol that includes FSH alone without any LH surge prevention regimens is not inferior to a protocol including FSH plus a GnRH antagonist in terms of the clinical outcome in a donor/recipient model. The results of the present study are expected to show whether the addition of the GnRH antagonist is necessary in terms of the frequency of LH secretory peaks and progesterone elevations >1 ng/mL during the administration of the GnRH antagonist according to the adopted frequency of blood sampling in all Units. |
format | Online Article Text |
id | pubmed-10095010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100950102023-04-13 Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study Messinis, Ioannis E. Messini, Christina I. Papanikolaou, Evangelos G. Makrakis, Evangelos Loutradis, Dimitrios Christoforidis, Nikolaos Arkoulis, Theodosis Anifandis, Georgios Daponte, Alexandros Siristatidis, Charalampos J Clin Med Communication Preliminary data have shown that it is possible to attempt in vitro fertilization (IVF) treatment in fresh cycles without the use of a gonadotropin-releasing hormone (GnRH) antagonist or any other medication to prevent the luteinizing hormone (LH) surge during ovarian stimulation. To date, there is no information on this topic in the context of a prospective controlled trial. However, as prevention of the LH surge is an established procedure in fresh cycles, the question is whether such a study can be performed in frozen cycles. We aim to perform a pilot study in order to compare the efficacy of a protocol using FSH alone with that of a protocol using follicle-stimulating hormone (FSH) plus a GnRH antagonist for controlled ovarian hyperstimulation (COH) in cycles of elective freezing in the context of a donor/recipient program. This is a seven-center, two-arm prospective pilot cohort study conducted at the respective Assisted Reproductive Units in Greece. The hypothesis to be tested is that an ovarian stimulation protocol that includes FSH alone without any LH surge prevention regimens is not inferior to a protocol including FSH plus a GnRH antagonist in terms of the clinical outcome in a donor/recipient model. The results of the present study are expected to show whether the addition of the GnRH antagonist is necessary in terms of the frequency of LH secretory peaks and progesterone elevations >1 ng/mL during the administration of the GnRH antagonist according to the adopted frequency of blood sampling in all Units. MDPI 2023-04-06 /pmc/articles/PMC10095010/ /pubmed/37048828 http://dx.doi.org/10.3390/jcm12072743 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Messinis, Ioannis E. Messini, Christina I. Papanikolaou, Evangelos G. Makrakis, Evangelos Loutradis, Dimitrios Christoforidis, Nikolaos Arkoulis, Theodosis Anifandis, Georgios Daponte, Alexandros Siristatidis, Charalampos Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study |
title | Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study |
title_full | Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study |
title_fullStr | Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study |
title_full_unstemmed | Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study |
title_short | Ovarian Stimulation with FSH Alone versus FSH plus a GnRH Antagonist for Elective Freezing in an Oocyte Donor/Recipient Programme: A Protocol for a Pilot Multicenter Observational Study |
title_sort | ovarian stimulation with fsh alone versus fsh plus a gnrh antagonist for elective freezing in an oocyte donor/recipient programme: a protocol for a pilot multicenter observational study |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095010/ https://www.ncbi.nlm.nih.gov/pubmed/37048828 http://dx.doi.org/10.3390/jcm12072743 |
work_keys_str_mv | AT messinisioannise ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT messinichristinai ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT papanikolaouevangelosg ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT makrakisevangelos ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT loutradisdimitrios ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT christoforidisnikolaos ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT arkoulistheodosis ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT anifandisgeorgios ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT dapontealexandros ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy AT siristatidischaralampos ovarianstimulationwithfshaloneversusfshplusagnrhantagonistforelectivefreezinginanoocytedonorrecipientprogrammeaprotocolforapilotmulticenterobservationalstudy |