Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7

This study aimed to enhance homology-directed repair (HDR) efficiency in CRISPR/Cas-mediated genome editing by targeting three key factors regulating the balance between HDR and non-homologous end joining (NHEJ): MAD2L2, SCAI, and Ligase IV. In order to achieve this, a cellular model using mutated e...

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Detalles Bibliográficos
Autores principales: Anuchina, Arina A., Zaynitdinova, Milyausha I., Demchenko, Anna G., Evtushenko, Nadezhda A., Lavrov, Alexander V., Smirnikhina, Svetlana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095018/
https://www.ncbi.nlm.nih.gov/pubmed/37047677
http://dx.doi.org/10.3390/ijms24076704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095018/
https://www.ncbi.nlm.nih.gov/pubmed/37047677
http://dx.doi.org/10.3390/ijms24076704

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