Cargando…

Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, originating from keratinocytes of the spinous layer. Numerous risk factors have been discovered for the initiation and growth of this type of cancer, such as exposure to UV and ionizing radiation, chemical carcinogens, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Cozma, Elena-Codruta, Banciu, Laura Madalina, Soare, Cristina, Cretoiu, Sanda-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095059/
https://www.ncbi.nlm.nih.gov/pubmed/37047618
http://dx.doi.org/10.3390/ijms24076646
_version_ 1785023990584049664
author Cozma, Elena-Codruta
Banciu, Laura Madalina
Soare, Cristina
Cretoiu, Sanda-Maria
author_facet Cozma, Elena-Codruta
Banciu, Laura Madalina
Soare, Cristina
Cretoiu, Sanda-Maria
author_sort Cozma, Elena-Codruta
collection PubMed
description Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, originating from keratinocytes of the spinous layer. Numerous risk factors have been discovered for the initiation and growth of this type of cancer, such as exposure to UV and ionizing radiation, chemical carcinogens, the presence of immunosuppression states, chronic inflammation, infections with high-risk viral strains, and, last but not least, the presence of diseases associated with genetic alterations. The important socio-economic impact, as well as the difficulty associated with therapy for advanced forms, has made the molecular mechanisms underlying this neoplasia more and more intensively studied, with the intention of achieving a better understanding and advancing the treatment of this pathology. This review aims to provide a brief foray into the molecular, genetic, and epigenetic aspects of this cancer, as well as the treatment methods, ranging from the first used to the latest targeted therapies.
format Online
Article
Text
id pubmed-10095059
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100950592023-04-13 Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma Cozma, Elena-Codruta Banciu, Laura Madalina Soare, Cristina Cretoiu, Sanda-Maria Int J Mol Sci Review Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, originating from keratinocytes of the spinous layer. Numerous risk factors have been discovered for the initiation and growth of this type of cancer, such as exposure to UV and ionizing radiation, chemical carcinogens, the presence of immunosuppression states, chronic inflammation, infections with high-risk viral strains, and, last but not least, the presence of diseases associated with genetic alterations. The important socio-economic impact, as well as the difficulty associated with therapy for advanced forms, has made the molecular mechanisms underlying this neoplasia more and more intensively studied, with the intention of achieving a better understanding and advancing the treatment of this pathology. This review aims to provide a brief foray into the molecular, genetic, and epigenetic aspects of this cancer, as well as the treatment methods, ranging from the first used to the latest targeted therapies. MDPI 2023-04-02 /pmc/articles/PMC10095059/ /pubmed/37047618 http://dx.doi.org/10.3390/ijms24076646 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cozma, Elena-Codruta
Banciu, Laura Madalina
Soare, Cristina
Cretoiu, Sanda-Maria
Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma
title Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma
title_full Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma
title_fullStr Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma
title_full_unstemmed Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma
title_short Update on the Molecular Pathology of Cutaneous Squamous Cell Carcinoma
title_sort update on the molecular pathology of cutaneous squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095059/
https://www.ncbi.nlm.nih.gov/pubmed/37047618
http://dx.doi.org/10.3390/ijms24076646
work_keys_str_mv AT cozmaelenacodruta updateonthemolecularpathologyofcutaneoussquamouscellcarcinoma
AT banciulauramadalina updateonthemolecularpathologyofcutaneoussquamouscellcarcinoma
AT soarecristina updateonthemolecularpathologyofcutaneoussquamouscellcarcinoma
AT cretoiusandamaria updateonthemolecularpathologyofcutaneoussquamouscellcarcinoma