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Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging

Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the result of changes in the environment without any mutation...

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Autores principales: Smith, Nicholas, Shirazi, Suzanna, Cakouros, Dimitrios, Gronthos, Stan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095074/
https://www.ncbi.nlm.nih.gov/pubmed/37047469
http://dx.doi.org/10.3390/ijms24076499
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author Smith, Nicholas
Shirazi, Suzanna
Cakouros, Dimitrios
Gronthos, Stan
author_facet Smith, Nicholas
Shirazi, Suzanna
Cakouros, Dimitrios
Gronthos, Stan
author_sort Smith, Nicholas
collection PubMed
description Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the result of changes in the environment without any mutation in the underlying DNA sequence. The epigenetic profiles of cells are dynamic and mediated by different mechanisms, including histone modifications, non-coding RNA-associated gene silencing and DNA methylation. Given the underlining role of dysfunctional mesenchymal tissues in common age-related skeletal diseases such as osteoporosis and osteoarthritis, investigations into skeletal stem cells or mesenchymal stem cells (MSC) and their functional deregulation during aging has been of great interest and how this is mediated by an evolving epigenetic landscape. The present review describes the recent findings in epigenetic changes of MSCs that effect growth and cell fate determination in the context of aging, diet, exercise and bone-related diseases.
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spelling pubmed-100950742023-04-13 Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging Smith, Nicholas Shirazi, Suzanna Cakouros, Dimitrios Gronthos, Stan Int J Mol Sci Review Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the result of changes in the environment without any mutation in the underlying DNA sequence. The epigenetic profiles of cells are dynamic and mediated by different mechanisms, including histone modifications, non-coding RNA-associated gene silencing and DNA methylation. Given the underlining role of dysfunctional mesenchymal tissues in common age-related skeletal diseases such as osteoporosis and osteoarthritis, investigations into skeletal stem cells or mesenchymal stem cells (MSC) and their functional deregulation during aging has been of great interest and how this is mediated by an evolving epigenetic landscape. The present review describes the recent findings in epigenetic changes of MSCs that effect growth and cell fate determination in the context of aging, diet, exercise and bone-related diseases. MDPI 2023-03-30 /pmc/articles/PMC10095074/ /pubmed/37047469 http://dx.doi.org/10.3390/ijms24076499 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Smith, Nicholas
Shirazi, Suzanna
Cakouros, Dimitrios
Gronthos, Stan
Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
title Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
title_full Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
title_fullStr Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
title_full_unstemmed Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
title_short Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
title_sort impact of environmental and epigenetic changes on mesenchymal stem cells during aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095074/
https://www.ncbi.nlm.nih.gov/pubmed/37047469
http://dx.doi.org/10.3390/ijms24076499
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