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Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the result of changes in the environment without any mutation...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095074/ https://www.ncbi.nlm.nih.gov/pubmed/37047469 http://dx.doi.org/10.3390/ijms24076499 |
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author | Smith, Nicholas Shirazi, Suzanna Cakouros, Dimitrios Gronthos, Stan |
author_facet | Smith, Nicholas Shirazi, Suzanna Cakouros, Dimitrios Gronthos, Stan |
author_sort | Smith, Nicholas |
collection | PubMed |
description | Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the result of changes in the environment without any mutation in the underlying DNA sequence. The epigenetic profiles of cells are dynamic and mediated by different mechanisms, including histone modifications, non-coding RNA-associated gene silencing and DNA methylation. Given the underlining role of dysfunctional mesenchymal tissues in common age-related skeletal diseases such as osteoporosis and osteoarthritis, investigations into skeletal stem cells or mesenchymal stem cells (MSC) and their functional deregulation during aging has been of great interest and how this is mediated by an evolving epigenetic landscape. The present review describes the recent findings in epigenetic changes of MSCs that effect growth and cell fate determination in the context of aging, diet, exercise and bone-related diseases. |
format | Online Article Text |
id | pubmed-10095074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100950742023-04-13 Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging Smith, Nicholas Shirazi, Suzanna Cakouros, Dimitrios Gronthos, Stan Int J Mol Sci Review Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the result of changes in the environment without any mutation in the underlying DNA sequence. The epigenetic profiles of cells are dynamic and mediated by different mechanisms, including histone modifications, non-coding RNA-associated gene silencing and DNA methylation. Given the underlining role of dysfunctional mesenchymal tissues in common age-related skeletal diseases such as osteoporosis and osteoarthritis, investigations into skeletal stem cells or mesenchymal stem cells (MSC) and their functional deregulation during aging has been of great interest and how this is mediated by an evolving epigenetic landscape. The present review describes the recent findings in epigenetic changes of MSCs that effect growth and cell fate determination in the context of aging, diet, exercise and bone-related diseases. MDPI 2023-03-30 /pmc/articles/PMC10095074/ /pubmed/37047469 http://dx.doi.org/10.3390/ijms24076499 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Smith, Nicholas Shirazi, Suzanna Cakouros, Dimitrios Gronthos, Stan Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging |
title | Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging |
title_full | Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging |
title_fullStr | Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging |
title_full_unstemmed | Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging |
title_short | Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging |
title_sort | impact of environmental and epigenetic changes on mesenchymal stem cells during aging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095074/ https://www.ncbi.nlm.nih.gov/pubmed/37047469 http://dx.doi.org/10.3390/ijms24076499 |
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