The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity

Bacterial nitroreductase enzymes that convert prodrugs to cytotoxins are valuable tools for creating transgenic targeted ablation models to study cellular function and cell-specific regeneration paradigms. We recently engineered a nitroreductase (“NTR 2.0”) for substantially enhanced reduction of th...

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Detalles Bibliográficos
Autores principales: Sharrock, Abigail V., Mumm, Jeff S., Bagdžiūnas, Gintautas, Čėnas, Narimantas, Arcus, Vickery L., Ackerley, David F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095097/
https://www.ncbi.nlm.nih.gov/pubmed/37047605
http://dx.doi.org/10.3390/ijms24076633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095097/
https://www.ncbi.nlm.nih.gov/pubmed/37047605
http://dx.doi.org/10.3390/ijms24076633

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