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The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity
Bacterial nitroreductase enzymes that convert prodrugs to cytotoxins are valuable tools for creating transgenic targeted ablation models to study cellular function and cell-specific regeneration paradigms. We recently engineered a nitroreductase (“NTR 2.0”) for substantially enhanced reduction of th...
Autores principales: | Sharrock, Abigail V., Mumm, Jeff S., Bagdžiūnas, Gintautas, Čėnas, Narimantas, Arcus, Vickery L., Ackerley, David F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095097/ https://www.ncbi.nlm.nih.gov/pubmed/37047605 http://dx.doi.org/10.3390/ijms24076633 |
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