Interaction of Terminal Oxidases with Amphipathic Molecules

The review focuses on recent advances regarding the effects of natural and artificial amphipathic compounds on terminal oxidases. Terminal oxidases are fascinating biomolecular devices which couple the oxidation of respiratory substrates with generation of a proton motive force used by the cell for...

Descripción completa

Detalles Bibliográficos
Autores principales: Azarkina, Natalia V., Borisov, Vitaliy B., Oleynikov, Ilya P., Sudakov, Roman V., Vygodina, Tatiana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095113/
https://www.ncbi.nlm.nih.gov/pubmed/37047401
http://dx.doi.org/10.3390/ijms24076428
_version_ 1785024004705222656
author Azarkina, Natalia V.
Borisov, Vitaliy B.
Oleynikov, Ilya P.
Sudakov, Roman V.
Vygodina, Tatiana V.
author_facet Azarkina, Natalia V.
Borisov, Vitaliy B.
Oleynikov, Ilya P.
Sudakov, Roman V.
Vygodina, Tatiana V.
author_sort Azarkina, Natalia V.
collection PubMed
description The review focuses on recent advances regarding the effects of natural and artificial amphipathic compounds on terminal oxidases. Terminal oxidases are fascinating biomolecular devices which couple the oxidation of respiratory substrates with generation of a proton motive force used by the cell for ATP production and other needs. The role of endogenous lipids in the enzyme structure and function is highlighted. The main regularities of the interaction between the most popular detergents and terminal oxidases of various types are described. A hypothesis about the physiological regulation of mitochondrial-type enzymes by lipid-soluble ligands is considered.
format Online
Article
Text
id pubmed-10095113
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100951132023-04-13 Interaction of Terminal Oxidases with Amphipathic Molecules Azarkina, Natalia V. Borisov, Vitaliy B. Oleynikov, Ilya P. Sudakov, Roman V. Vygodina, Tatiana V. Int J Mol Sci Review The review focuses on recent advances regarding the effects of natural and artificial amphipathic compounds on terminal oxidases. Terminal oxidases are fascinating biomolecular devices which couple the oxidation of respiratory substrates with generation of a proton motive force used by the cell for ATP production and other needs. The role of endogenous lipids in the enzyme structure and function is highlighted. The main regularities of the interaction between the most popular detergents and terminal oxidases of various types are described. A hypothesis about the physiological regulation of mitochondrial-type enzymes by lipid-soluble ligands is considered. MDPI 2023-03-29 /pmc/articles/PMC10095113/ /pubmed/37047401 http://dx.doi.org/10.3390/ijms24076428 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Azarkina, Natalia V.
Borisov, Vitaliy B.
Oleynikov, Ilya P.
Sudakov, Roman V.
Vygodina, Tatiana V.
Interaction of Terminal Oxidases with Amphipathic Molecules
title Interaction of Terminal Oxidases with Amphipathic Molecules
title_full Interaction of Terminal Oxidases with Amphipathic Molecules
title_fullStr Interaction of Terminal Oxidases with Amphipathic Molecules
title_full_unstemmed Interaction of Terminal Oxidases with Amphipathic Molecules
title_short Interaction of Terminal Oxidases with Amphipathic Molecules
title_sort interaction of terminal oxidases with amphipathic molecules
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095113/
https://www.ncbi.nlm.nih.gov/pubmed/37047401
http://dx.doi.org/10.3390/ijms24076428
work_keys_str_mv AT azarkinanataliav interactionofterminaloxidaseswithamphipathicmolecules
AT borisovvitaliyb interactionofterminaloxidaseswithamphipathicmolecules
AT oleynikovilyap interactionofterminaloxidaseswithamphipathicmolecules
AT sudakovromanv interactionofterminaloxidaseswithamphipathicmolecules
AT vygodinatatianav interactionofterminaloxidaseswithamphipathicmolecules

Ejemplares similares