Evolution-Informed Strategies for Combating Drug Resistance in Cancer

The ever-changing nature of cancer poses the most difficult challenge oncologists face today. Cancer’s remarkable adaptability has inspired many to work toward understanding the evolutionary dynamics that underlie this disease in hopes of learning new ways to fight it. Eco-evolutionary dynamics of a...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin-Rahardja, Kristi, Weaver, Davis T., Scarborough, Jessica A., Scott, Jacob G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095117/
https://www.ncbi.nlm.nih.gov/pubmed/37047714
http://dx.doi.org/10.3390/ijms24076738
_version_ 1785024005666766848
author Lin-Rahardja, Kristi
Weaver, Davis T.
Scarborough, Jessica A.
Scott, Jacob G.
author_facet Lin-Rahardja, Kristi
Weaver, Davis T.
Scarborough, Jessica A.
Scott, Jacob G.
author_sort Lin-Rahardja, Kristi
collection PubMed
description The ever-changing nature of cancer poses the most difficult challenge oncologists face today. Cancer’s remarkable adaptability has inspired many to work toward understanding the evolutionary dynamics that underlie this disease in hopes of learning new ways to fight it. Eco-evolutionary dynamics of a tumor are not accounted for in most standard treatment regimens, but exploiting them would help us combat treatment-resistant effectively. Here, we outline several notable efforts to exploit these dynamics and circumvent drug resistance in cancer.
format Online
Article
Text
id pubmed-10095117
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100951172023-04-13 Evolution-Informed Strategies for Combating Drug Resistance in Cancer Lin-Rahardja, Kristi Weaver, Davis T. Scarborough, Jessica A. Scott, Jacob G. Int J Mol Sci Review The ever-changing nature of cancer poses the most difficult challenge oncologists face today. Cancer’s remarkable adaptability has inspired many to work toward understanding the evolutionary dynamics that underlie this disease in hopes of learning new ways to fight it. Eco-evolutionary dynamics of a tumor are not accounted for in most standard treatment regimens, but exploiting them would help us combat treatment-resistant effectively. Here, we outline several notable efforts to exploit these dynamics and circumvent drug resistance in cancer. MDPI 2023-04-04 /pmc/articles/PMC10095117/ /pubmed/37047714 http://dx.doi.org/10.3390/ijms24076738 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin-Rahardja, Kristi
Weaver, Davis T.
Scarborough, Jessica A.
Scott, Jacob G.
Evolution-Informed Strategies for Combating Drug Resistance in Cancer
title Evolution-Informed Strategies for Combating Drug Resistance in Cancer
title_full Evolution-Informed Strategies for Combating Drug Resistance in Cancer
title_fullStr Evolution-Informed Strategies for Combating Drug Resistance in Cancer
title_full_unstemmed Evolution-Informed Strategies for Combating Drug Resistance in Cancer
title_short Evolution-Informed Strategies for Combating Drug Resistance in Cancer
title_sort evolution-informed strategies for combating drug resistance in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095117/
https://www.ncbi.nlm.nih.gov/pubmed/37047714
http://dx.doi.org/10.3390/ijms24076738
work_keys_str_mv AT linrahardjakristi evolutioninformedstrategiesforcombatingdrugresistanceincancer
AT weaverdavist evolutioninformedstrategiesforcombatingdrugresistanceincancer
AT scarboroughjessicaa evolutioninformedstrategiesforcombatingdrugresistanceincancer
AT scottjacobg evolutioninformedstrategiesforcombatingdrugresistanceincancer

Ejemplares similares