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Access to High-Cost Biological Agents: Perceptions of Brazilian Patients with Inflammatory Bowel Diseases
Background and aims: Brazilian patients with inflammatory bowel diseases (IBD) requiring therapy with biological agents usually have access to medicines through the National Unified Health Care System (SUS). This study aimed to analyze Brazilian IBD patient perception regarding access (availability...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095198/ https://www.ncbi.nlm.nih.gov/pubmed/37048755 http://dx.doi.org/10.3390/jcm12072672 |
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author | Parra, Rogerio Serafim da Costa Ferreira, Sandro Machado, Vanessa Foresto Nigro, Cintia Maura Caseiro da Rocha, José Joaquim Ribeiro de Almeida Troncon, Luiz Ernesto Feres, Omar |
author_facet | Parra, Rogerio Serafim da Costa Ferreira, Sandro Machado, Vanessa Foresto Nigro, Cintia Maura Caseiro da Rocha, José Joaquim Ribeiro de Almeida Troncon, Luiz Ernesto Feres, Omar |
author_sort | Parra, Rogerio Serafim |
collection | PubMed |
description | Background and aims: Brazilian patients with inflammatory bowel diseases (IBD) requiring therapy with biological agents usually have access to medicines through the National Unified Health Care System (SUS). This study aimed to analyze Brazilian IBD patient perception regarding access (availability and provision quality) to high-cost drugs in the public health care system. Methods: A questionnaire-based survey was carried out in an IBD referral center in Brazil. All adult patients with an established diagnosis of ulcerative colitis (UC) or Crohn’s disease (CD) that use biological therapy were invited to participate. Data were collected on the biological in use, lack of distribution (number of absences, average time to regularization, impairment in patient treatment), and difficulties reported by patients in obtaining the drugs. Results: Overall, 205 patients met the inclusion criteria and answered the questionnaire. Most of the patients had CD (n = 161, 78.5%), nearly half of them (n = 104, 50.7%) were female; 87 patients (42.4%) were unemployed, and of these, 40 patients (19.5%) had government assistance as the main source of income. Regarding the medications used, infliximab (n = 128, 62.5%) was the most used medication, followed by adalimumab (n = 39, 19.0%). Most patients (n = 172, 83.9%) reported at least one failed delivery of biological medicine in the last year, with a single shortage in forty-two patients (24.4%), at least two shortages in forty-seven patients (27.3%), and three or more shortages in seventy-eight patients (45.3%). The average time to regularize the distribution was up to 1 month in 44 cases (25.6%), up to 2 months in 64 cases (37.2%), and more than 3 months in 56 patients (32.6%). Among patients who reported delays, 101 patients (58.7%) felt that it may have impaired their treatment. Conclusion: Brazilian IBD patients reported high rates of failure to dispense biological drugs by the national healthcare system within one year. Our data highlight the need for improvement in this system for the correct supply of medication to avoid treatment failure and relapse. |
format | Online Article Text |
id | pubmed-10095198 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100951982023-04-13 Access to High-Cost Biological Agents: Perceptions of Brazilian Patients with Inflammatory Bowel Diseases Parra, Rogerio Serafim da Costa Ferreira, Sandro Machado, Vanessa Foresto Nigro, Cintia Maura Caseiro da Rocha, José Joaquim Ribeiro de Almeida Troncon, Luiz Ernesto Feres, Omar J Clin Med Article Background and aims: Brazilian patients with inflammatory bowel diseases (IBD) requiring therapy with biological agents usually have access to medicines through the National Unified Health Care System (SUS). This study aimed to analyze Brazilian IBD patient perception regarding access (availability and provision quality) to high-cost drugs in the public health care system. Methods: A questionnaire-based survey was carried out in an IBD referral center in Brazil. All adult patients with an established diagnosis of ulcerative colitis (UC) or Crohn’s disease (CD) that use biological therapy were invited to participate. Data were collected on the biological in use, lack of distribution (number of absences, average time to regularization, impairment in patient treatment), and difficulties reported by patients in obtaining the drugs. Results: Overall, 205 patients met the inclusion criteria and answered the questionnaire. Most of the patients had CD (n = 161, 78.5%), nearly half of them (n = 104, 50.7%) were female; 87 patients (42.4%) were unemployed, and of these, 40 patients (19.5%) had government assistance as the main source of income. Regarding the medications used, infliximab (n = 128, 62.5%) was the most used medication, followed by adalimumab (n = 39, 19.0%). Most patients (n = 172, 83.9%) reported at least one failed delivery of biological medicine in the last year, with a single shortage in forty-two patients (24.4%), at least two shortages in forty-seven patients (27.3%), and three or more shortages in seventy-eight patients (45.3%). The average time to regularize the distribution was up to 1 month in 44 cases (25.6%), up to 2 months in 64 cases (37.2%), and more than 3 months in 56 patients (32.6%). Among patients who reported delays, 101 patients (58.7%) felt that it may have impaired their treatment. Conclusion: Brazilian IBD patients reported high rates of failure to dispense biological drugs by the national healthcare system within one year. Our data highlight the need for improvement in this system for the correct supply of medication to avoid treatment failure and relapse. MDPI 2023-04-03 /pmc/articles/PMC10095198/ /pubmed/37048755 http://dx.doi.org/10.3390/jcm12072672 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Parra, Rogerio Serafim da Costa Ferreira, Sandro Machado, Vanessa Foresto Nigro, Cintia Maura Caseiro da Rocha, José Joaquim Ribeiro de Almeida Troncon, Luiz Ernesto Feres, Omar Access to High-Cost Biological Agents: Perceptions of Brazilian Patients with Inflammatory Bowel Diseases |
title | Access to High-Cost Biological Agents: Perceptions of Brazilian Patients with Inflammatory Bowel Diseases |
title_full | Access to High-Cost Biological Agents: Perceptions of Brazilian Patients with Inflammatory Bowel Diseases |
title_fullStr | Access to High-Cost Biological Agents: Perceptions of Brazilian Patients with Inflammatory Bowel Diseases |
title_full_unstemmed | Access to High-Cost Biological Agents: Perceptions of Brazilian Patients with Inflammatory Bowel Diseases |
title_short | Access to High-Cost Biological Agents: Perceptions of Brazilian Patients with Inflammatory Bowel Diseases |
title_sort | access to high-cost biological agents: perceptions of brazilian patients with inflammatory bowel diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095198/ https://www.ncbi.nlm.nih.gov/pubmed/37048755 http://dx.doi.org/10.3390/jcm12072672 |
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