A Dual-Function “TRE-Lox” System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D

Commonly employed methods for reversibly disrupting gene expression, such as those based on RNAi or CRISPRi, are rarely capable of achieving >80–90% downregulation, making them unsuitable for targeting genes that require more complete disruption to elicit a phenotype. Genetic deletion, on the oth...

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Detalles Bibliográficos
Autores principales: Terron, Heather M., Maranan, Derek S., Burgard, Luke A., LaFerla, Frank M., Lane, Shelley, Leissring, Malcolm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095275/
https://www.ncbi.nlm.nih.gov/pubmed/37047718
http://dx.doi.org/10.3390/ijms24076745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095275/
https://www.ncbi.nlm.nih.gov/pubmed/37047718
http://dx.doi.org/10.3390/ijms24076745

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