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S100B, Actor and Biomarker of Mild Traumatic Brain Injury

Mild traumatic brain injury (mTBI) accounts for approximately 80% of all TBI cases and is a growing source of morbidity and mortality worldwide. To improve the management of children and adults with mTBI, a series of candidate biomarkers have been investigated in recent years. In this context, the m...

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Autores principales: Oris, Charlotte, Kahouadji, Samy, Durif, Julie, Bouvier, Damien, Sapin, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095287/
https://www.ncbi.nlm.nih.gov/pubmed/37047574
http://dx.doi.org/10.3390/ijms24076602
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author Oris, Charlotte
Kahouadji, Samy
Durif, Julie
Bouvier, Damien
Sapin, Vincent
author_facet Oris, Charlotte
Kahouadji, Samy
Durif, Julie
Bouvier, Damien
Sapin, Vincent
author_sort Oris, Charlotte
collection PubMed
description Mild traumatic brain injury (mTBI) accounts for approximately 80% of all TBI cases and is a growing source of morbidity and mortality worldwide. To improve the management of children and adults with mTBI, a series of candidate biomarkers have been investigated in recent years. In this context, the measurement of blood biomarkers in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. In athletes, improved management of sports-related concussions is also sought to ensure athletes’ safety. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. In addition to its use as a diagnostic biomarker, S100B plays an active role in the molecular pathogenic processes accompanying acute brain injury. This review describes S100B protein as a diagnostic tool as well as a potential therapeutic target in patients with mTBI.
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spelling pubmed-100952872023-04-13 S100B, Actor and Biomarker of Mild Traumatic Brain Injury Oris, Charlotte Kahouadji, Samy Durif, Julie Bouvier, Damien Sapin, Vincent Int J Mol Sci Review Mild traumatic brain injury (mTBI) accounts for approximately 80% of all TBI cases and is a growing source of morbidity and mortality worldwide. To improve the management of children and adults with mTBI, a series of candidate biomarkers have been investigated in recent years. In this context, the measurement of blood biomarkers in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. In athletes, improved management of sports-related concussions is also sought to ensure athletes’ safety. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. In addition to its use as a diagnostic biomarker, S100B plays an active role in the molecular pathogenic processes accompanying acute brain injury. This review describes S100B protein as a diagnostic tool as well as a potential therapeutic target in patients with mTBI. MDPI 2023-04-01 /pmc/articles/PMC10095287/ /pubmed/37047574 http://dx.doi.org/10.3390/ijms24076602 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oris, Charlotte
Kahouadji, Samy
Durif, Julie
Bouvier, Damien
Sapin, Vincent
S100B, Actor and Biomarker of Mild Traumatic Brain Injury
title S100B, Actor and Biomarker of Mild Traumatic Brain Injury
title_full S100B, Actor and Biomarker of Mild Traumatic Brain Injury
title_fullStr S100B, Actor and Biomarker of Mild Traumatic Brain Injury
title_full_unstemmed S100B, Actor and Biomarker of Mild Traumatic Brain Injury
title_short S100B, Actor and Biomarker of Mild Traumatic Brain Injury
title_sort s100b, actor and biomarker of mild traumatic brain injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095287/
https://www.ncbi.nlm.nih.gov/pubmed/37047574
http://dx.doi.org/10.3390/ijms24076602
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