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A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer
Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors. Hormone therapy using antiestrogens is the gold stand...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095386/ https://www.ncbi.nlm.nih.gov/pubmed/37047814 http://dx.doi.org/10.3390/ijms24076834 |
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author | Clusan, Léa Ferrière, François Flouriot, Gilles Pakdel, Farzad |
author_facet | Clusan, Léa Ferrière, François Flouriot, Gilles Pakdel, Farzad |
author_sort | Clusan, Léa |
collection | PubMed |
description | Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors. Hormone therapy using antiestrogens is the gold standard, but resistance to these treatments invariably occurs through various biological mechanisms, such as changes in estrogen receptor activity, mutations in the ESR1 gene, aberrant activation of the PI3K pathway or cell cycle dysregulations. All these factors have led to the development of new therapies, such as selective estrogen receptor degraders (SERDs), or combination therapies with cyclin-dependent kinases (CDK) 4/6 or PI3K inhibitors. Therefore, understanding the estrogen pathway is essential for the treatment and new drug development of hormone-dependent cancers. This mini-review summarizes current literature on the signalization, mechanisms of action and clinical implications of estrogen receptors in breast cancer. |
format | Online Article Text |
id | pubmed-10095386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100953862023-04-13 A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer Clusan, Léa Ferrière, François Flouriot, Gilles Pakdel, Farzad Int J Mol Sci Review Breast cancer is the most common cancer and the deadliest among women worldwide. Estrogen signaling is closely associated with hormone-dependent breast cancer (estrogen and progesterone receptor positive), which accounts for two-thirds of tumors. Hormone therapy using antiestrogens is the gold standard, but resistance to these treatments invariably occurs through various biological mechanisms, such as changes in estrogen receptor activity, mutations in the ESR1 gene, aberrant activation of the PI3K pathway or cell cycle dysregulations. All these factors have led to the development of new therapies, such as selective estrogen receptor degraders (SERDs), or combination therapies with cyclin-dependent kinases (CDK) 4/6 or PI3K inhibitors. Therefore, understanding the estrogen pathway is essential for the treatment and new drug development of hormone-dependent cancers. This mini-review summarizes current literature on the signalization, mechanisms of action and clinical implications of estrogen receptors in breast cancer. MDPI 2023-04-06 /pmc/articles/PMC10095386/ /pubmed/37047814 http://dx.doi.org/10.3390/ijms24076834 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Clusan, Léa Ferrière, François Flouriot, Gilles Pakdel, Farzad A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer |
title | A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer |
title_full | A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer |
title_fullStr | A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer |
title_full_unstemmed | A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer |
title_short | A Basic Review on Estrogen Receptor Signaling Pathways in Breast Cancer |
title_sort | basic review on estrogen receptor signaling pathways in breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095386/ https://www.ncbi.nlm.nih.gov/pubmed/37047814 http://dx.doi.org/10.3390/ijms24076834 |
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