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Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles

The rate of monozygotic twinning (MZT) has seen a gradual increase in recent years. Numerous parameters involved in ART procedures are blamed for this surge, even though the exact explanation is as yet unknown. Our study’s objectives were to determine the risk variables for monozygotic twinning afte...

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Autores principales: Kadam, Nikit, Woodhead, George, Kellam, Louise, Campbell, Alison, Jayaprakasan, Kanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095500/
https://www.ncbi.nlm.nih.gov/pubmed/37048676
http://dx.doi.org/10.3390/jcm12072593
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author Kadam, Nikit
Woodhead, George
Kellam, Louise
Campbell, Alison
Jayaprakasan, Kanna
author_facet Kadam, Nikit
Woodhead, George
Kellam, Louise
Campbell, Alison
Jayaprakasan, Kanna
author_sort Kadam, Nikit
collection PubMed
description The rate of monozygotic twinning (MZT) has seen a gradual increase in recent years. Numerous parameters involved in ART procedures are blamed for this surge, even though the exact explanation is as yet unknown. Our study’s objectives were to determine the risk variables for monozygotic twinning after ART and to estimate their prevalence. We examined 25,794 IVF cycles for the incidence of monozygotic twinning in this observational analysis. Our study, which was carried out across seven tertiary IVF centres over the course of four years, found an overall MZT rate of 0.37% per embryo transfer procedure and 0.88% of all pregnancies. Monozygotic twinning was more commonly seen in fresh single-embryo transfer (SET) and blastocyst transfer cycles. Larger multicentre studies are needed to explore the potential risk variables.
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spelling pubmed-100955002023-04-13 Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles Kadam, Nikit Woodhead, George Kellam, Louise Campbell, Alison Jayaprakasan, Kanna J Clin Med Brief Report The rate of monozygotic twinning (MZT) has seen a gradual increase in recent years. Numerous parameters involved in ART procedures are blamed for this surge, even though the exact explanation is as yet unknown. Our study’s objectives were to determine the risk variables for monozygotic twinning after ART and to estimate their prevalence. We examined 25,794 IVF cycles for the incidence of monozygotic twinning in this observational analysis. Our study, which was carried out across seven tertiary IVF centres over the course of four years, found an overall MZT rate of 0.37% per embryo transfer procedure and 0.88% of all pregnancies. Monozygotic twinning was more commonly seen in fresh single-embryo transfer (SET) and blastocyst transfer cycles. Larger multicentre studies are needed to explore the potential risk variables. MDPI 2023-03-30 /pmc/articles/PMC10095500/ /pubmed/37048676 http://dx.doi.org/10.3390/jcm12072593 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Kadam, Nikit
Woodhead, George
Kellam, Louise
Campbell, Alison
Jayaprakasan, Kanna
Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles
title Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles
title_full Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles
title_fullStr Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles
title_full_unstemmed Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles
title_short Odds and Predictors of Monozygotic Twinning in a Multicentre Cohort of 25,794 IVF Cycles
title_sort odds and predictors of monozygotic twinning in a multicentre cohort of 25,794 ivf cycles
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095500/
https://www.ncbi.nlm.nih.gov/pubmed/37048676
http://dx.doi.org/10.3390/jcm12072593
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