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Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up

Background: Despite its high prevalence, the clinical course of pediatric migraine has not been fully understood, and previous studies present conflicting results. We present here the findings of a 10-year follow-up study involving children with severe migraine pain admitted to our emergency departm...

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Autores principales: Manzo, Maria Laura, Reina, Federica, Correnti, Edvige, D’Aiuto, Francesca, D’Agnano, Daniela, Santangelo, Andrea, Vetri, Luigi, Santangelo, Giuseppe, Maniscalco, Laura, Tripi, Gabriele, Sciruicchio, Vittorio, Raieli, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095507/
https://www.ncbi.nlm.nih.gov/pubmed/37048559
http://dx.doi.org/10.3390/jcm12072475
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author Manzo, Maria Laura
Reina, Federica
Correnti, Edvige
D’Aiuto, Francesca
D’Agnano, Daniela
Santangelo, Andrea
Vetri, Luigi
Santangelo, Giuseppe
Maniscalco, Laura
Tripi, Gabriele
Sciruicchio, Vittorio
Raieli, Vincenzo
author_facet Manzo, Maria Laura
Reina, Federica
Correnti, Edvige
D’Aiuto, Francesca
D’Agnano, Daniela
Santangelo, Andrea
Vetri, Luigi
Santangelo, Giuseppe
Maniscalco, Laura
Tripi, Gabriele
Sciruicchio, Vittorio
Raieli, Vincenzo
author_sort Manzo, Maria Laura
collection PubMed
description Background: Despite its high prevalence, the clinical course of pediatric migraine has not been fully understood, and previous studies present conflicting results. We present here the findings of a 10-year follow-up study involving children with severe migraine pain admitted to our emergency department. Furthermore, all studies were carried out on selected outpatient clinical case studies. Our aim was to evaluate a population of migraine children admitted to an emergency department because of increased severity or frequency of pain or even because of very anxious parents concerning their child’s headache in order to describe their long-term outcomes, whether it differed from that of outpatient populations and to identify possible predictors of prognosis. Methods: We recruited 80 subjects with migraine headaches (mean age 8 years with a range of 4–14 years, 50% females), attending the baseline examination of a population admitted for a headache to the Emergency Department in the first half year of 2012. Of the 80 subjects, 48 (60%) were eligible for follow-up in 2022. We included in our study only patients diagnosed with migraine, according to the diagnostic criteria of the International Classification of Headache Disorders. All were contacted by telephone, and a semi-structured questionnaire was provided to them by email. The association between several possible prognostic factors (gender, familiar neurologic disorders, prenatal and perinatal disorders, social activities, sleep disorders, etc.) and the long-term persistence of migraine headaches were explored using logistic regression analysis. Results: Of 48 subjects with migraine headaches at baseline, 31 (65%) had persistent migraine, and 17 (35%) experienced remission. The preliminary results showed that the presence of neurologic disorders in parents (p < 0.01—odds ratio 9.34 (2.53–41.64) and sleep disorders (p < 0.01—odds ratio 13.18 (2.25–252.74) significantly predicted the 10-year persistence of migraine headaches, while the other considered predictors were found not to influence prognosis. Conclusions: To our knowledge, this was the first study conducted on a selected pediatric population upon admission to the emergency room. Our study suggests that a population of pediatric migraine selected for admission to the emergency department also shows a favorable long-term prognosis, like the studies conducted in the outpatient sample. Familial neurological comorbidity and sleep disorders were unfavorable factors for predicting good outcomes.
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spelling pubmed-100955072023-04-13 Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up Manzo, Maria Laura Reina, Federica Correnti, Edvige D’Aiuto, Francesca D’Agnano, Daniela Santangelo, Andrea Vetri, Luigi Santangelo, Giuseppe Maniscalco, Laura Tripi, Gabriele Sciruicchio, Vittorio Raieli, Vincenzo J Clin Med Article Background: Despite its high prevalence, the clinical course of pediatric migraine has not been fully understood, and previous studies present conflicting results. We present here the findings of a 10-year follow-up study involving children with severe migraine pain admitted to our emergency department. Furthermore, all studies were carried out on selected outpatient clinical case studies. Our aim was to evaluate a population of migraine children admitted to an emergency department because of increased severity or frequency of pain or even because of very anxious parents concerning their child’s headache in order to describe their long-term outcomes, whether it differed from that of outpatient populations and to identify possible predictors of prognosis. Methods: We recruited 80 subjects with migraine headaches (mean age 8 years with a range of 4–14 years, 50% females), attending the baseline examination of a population admitted for a headache to the Emergency Department in the first half year of 2012. Of the 80 subjects, 48 (60%) were eligible for follow-up in 2022. We included in our study only patients diagnosed with migraine, according to the diagnostic criteria of the International Classification of Headache Disorders. All were contacted by telephone, and a semi-structured questionnaire was provided to them by email. The association between several possible prognostic factors (gender, familiar neurologic disorders, prenatal and perinatal disorders, social activities, sleep disorders, etc.) and the long-term persistence of migraine headaches were explored using logistic regression analysis. Results: Of 48 subjects with migraine headaches at baseline, 31 (65%) had persistent migraine, and 17 (35%) experienced remission. The preliminary results showed that the presence of neurologic disorders in parents (p < 0.01—odds ratio 9.34 (2.53–41.64) and sleep disorders (p < 0.01—odds ratio 13.18 (2.25–252.74) significantly predicted the 10-year persistence of migraine headaches, while the other considered predictors were found not to influence prognosis. Conclusions: To our knowledge, this was the first study conducted on a selected pediatric population upon admission to the emergency room. Our study suggests that a population of pediatric migraine selected for admission to the emergency department also shows a favorable long-term prognosis, like the studies conducted in the outpatient sample. Familial neurological comorbidity and sleep disorders were unfavorable factors for predicting good outcomes. MDPI 2023-03-24 /pmc/articles/PMC10095507/ /pubmed/37048559 http://dx.doi.org/10.3390/jcm12072475 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manzo, Maria Laura
Reina, Federica
Correnti, Edvige
D’Aiuto, Francesca
D’Agnano, Daniela
Santangelo, Andrea
Vetri, Luigi
Santangelo, Giuseppe
Maniscalco, Laura
Tripi, Gabriele
Sciruicchio, Vittorio
Raieli, Vincenzo
Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up
title Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up
title_full Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up
title_fullStr Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up
title_full_unstemmed Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up
title_short Evolution of Pediatric Migraine Patients Admitted at an Emergency Department after a 10-Year Follow-Up
title_sort evolution of pediatric migraine patients admitted at an emergency department after a 10-year follow-up
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095507/
https://www.ncbi.nlm.nih.gov/pubmed/37048559
http://dx.doi.org/10.3390/jcm12072475
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