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Preleukemic Fusion Genes Induced via Ionizing Radiation

Although the prevalence of leukemia is increasing, the agents responsible for this increase are not definitely known. While ionizing radiation (IR) was classified as a group one carcinogen by the IARC, the IR-induced cancers, including leukemia, are indistinguishable from those that are caused by ot...

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Autores principales: Kosik, Pavol, Skorvaga, Milan, Belyaev, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095576/
https://www.ncbi.nlm.nih.gov/pubmed/37047553
http://dx.doi.org/10.3390/ijms24076580
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author Kosik, Pavol
Skorvaga, Milan
Belyaev, Igor
author_facet Kosik, Pavol
Skorvaga, Milan
Belyaev, Igor
author_sort Kosik, Pavol
collection PubMed
description Although the prevalence of leukemia is increasing, the agents responsible for this increase are not definitely known. While ionizing radiation (IR) was classified as a group one carcinogen by the IARC, the IR-induced cancers, including leukemia, are indistinguishable from those that are caused by other factors, so the risk estimation relies on epidemiological data. Several epidemiological studies on atomic bomb survivors and persons undergoing IR exposure during medical investigations or radiotherapy showed an association between radiation and leukemia. IR is also known to induce chromosomal translocations. Specific chromosomal translocations resulting in preleukemic fusion genes (PFGs) are generally accepted to be the first hit in the onset of many leukemias. Several studies indicated that incidence of PFGs in healthy newborns is up to 100-times higher than childhood leukemia with the same chromosomal aberrations. Because of this fact, it has been suggested that PFGs are not able to induce leukemia alone, but secondary mutations are necessary. PFGs also have to occur in specific cell populations of hematopoetic stem cells with higher leukemogenic potential. In this review, we describe the connection between IR, PFGs, and cancer, focusing on recurrent PFGs where an association with IR has been established.
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spelling pubmed-100955762023-04-13 Preleukemic Fusion Genes Induced via Ionizing Radiation Kosik, Pavol Skorvaga, Milan Belyaev, Igor Int J Mol Sci Review Although the prevalence of leukemia is increasing, the agents responsible for this increase are not definitely known. While ionizing radiation (IR) was classified as a group one carcinogen by the IARC, the IR-induced cancers, including leukemia, are indistinguishable from those that are caused by other factors, so the risk estimation relies on epidemiological data. Several epidemiological studies on atomic bomb survivors and persons undergoing IR exposure during medical investigations or radiotherapy showed an association between radiation and leukemia. IR is also known to induce chromosomal translocations. Specific chromosomal translocations resulting in preleukemic fusion genes (PFGs) are generally accepted to be the first hit in the onset of many leukemias. Several studies indicated that incidence of PFGs in healthy newborns is up to 100-times higher than childhood leukemia with the same chromosomal aberrations. Because of this fact, it has been suggested that PFGs are not able to induce leukemia alone, but secondary mutations are necessary. PFGs also have to occur in specific cell populations of hematopoetic stem cells with higher leukemogenic potential. In this review, we describe the connection between IR, PFGs, and cancer, focusing on recurrent PFGs where an association with IR has been established. MDPI 2023-04-01 /pmc/articles/PMC10095576/ /pubmed/37047553 http://dx.doi.org/10.3390/ijms24076580 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kosik, Pavol
Skorvaga, Milan
Belyaev, Igor
Preleukemic Fusion Genes Induced via Ionizing Radiation
title Preleukemic Fusion Genes Induced via Ionizing Radiation
title_full Preleukemic Fusion Genes Induced via Ionizing Radiation
title_fullStr Preleukemic Fusion Genes Induced via Ionizing Radiation
title_full_unstemmed Preleukemic Fusion Genes Induced via Ionizing Radiation
title_short Preleukemic Fusion Genes Induced via Ionizing Radiation
title_sort preleukemic fusion genes induced via ionizing radiation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095576/
https://www.ncbi.nlm.nih.gov/pubmed/37047553
http://dx.doi.org/10.3390/ijms24076580
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