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A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota

Background: Male contraceptive approaches besides tubal sterilization involve vasectomy and represent the method of choice among midlife men in developing countries thanks to many advantages. However, the subsidiary consequences of this intervention are insufficiently explored since the involved mec...

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Autores principales: Doroftei, Bogdan, Ilie, Ovidiu-Dumitru, Maftei, Radu, Scripcariu, Ioana-Sadyie, Armeanu, Theodora, Stoian, Irina-Liviana, Ilea, Ciprian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095584/
https://www.ncbi.nlm.nih.gov/pubmed/37048754
http://dx.doi.org/10.3390/jcm12072671
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author Doroftei, Bogdan
Ilie, Ovidiu-Dumitru
Maftei, Radu
Scripcariu, Ioana-Sadyie
Armeanu, Theodora
Stoian, Irina-Liviana
Ilea, Ciprian
author_facet Doroftei, Bogdan
Ilie, Ovidiu-Dumitru
Maftei, Radu
Scripcariu, Ioana-Sadyie
Armeanu, Theodora
Stoian, Irina-Liviana
Ilea, Ciprian
author_sort Doroftei, Bogdan
collection PubMed
description Background: Male contraceptive approaches besides tubal sterilization involve vasectomy and represent the method of choice among midlife men in developing countries thanks to many advantages. However, the subsidiary consequences of this intervention are insufficiently explored since the involved mechanisms may offer insight into a much more complex picture. Methods: Thus, in this manuscript, we aimed to reunite all available data by searching three separate academic database(s) (PubMed, Web of Knowledge, and Scopus) published in the past two decades by covering the interval 2000–2023 and using a predefined set of keywords and strings involving “oxidative stress” (OS), “inflammation”, and “semen microbiota” in combination with “humans”, “rats”, and “mice”. Results: By following all evidence that fits in the pre-, post-, and vasectomy reversal (VR) stages, we identified a total of n = 210 studies from which only n = 21 were finally included following two procedures of eligibility evaluation. Conclusions: The topic surrounding this intricate landscape has created debate since the current evidence is contradictory, limited, or does not exist. Starting from this consideration, we argue that further research is mandatory to decipher how a vasectomy might disturb homeostasis.
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spelling pubmed-100955842023-04-13 A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota Doroftei, Bogdan Ilie, Ovidiu-Dumitru Maftei, Radu Scripcariu, Ioana-Sadyie Armeanu, Theodora Stoian, Irina-Liviana Ilea, Ciprian J Clin Med Review Background: Male contraceptive approaches besides tubal sterilization involve vasectomy and represent the method of choice among midlife men in developing countries thanks to many advantages. However, the subsidiary consequences of this intervention are insufficiently explored since the involved mechanisms may offer insight into a much more complex picture. Methods: Thus, in this manuscript, we aimed to reunite all available data by searching three separate academic database(s) (PubMed, Web of Knowledge, and Scopus) published in the past two decades by covering the interval 2000–2023 and using a predefined set of keywords and strings involving “oxidative stress” (OS), “inflammation”, and “semen microbiota” in combination with “humans”, “rats”, and “mice”. Results: By following all evidence that fits in the pre-, post-, and vasectomy reversal (VR) stages, we identified a total of n = 210 studies from which only n = 21 were finally included following two procedures of eligibility evaluation. Conclusions: The topic surrounding this intricate landscape has created debate since the current evidence is contradictory, limited, or does not exist. Starting from this consideration, we argue that further research is mandatory to decipher how a vasectomy might disturb homeostasis. MDPI 2023-04-03 /pmc/articles/PMC10095584/ /pubmed/37048754 http://dx.doi.org/10.3390/jcm12072671 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Doroftei, Bogdan
Ilie, Ovidiu-Dumitru
Maftei, Radu
Scripcariu, Ioana-Sadyie
Armeanu, Theodora
Stoian, Irina-Liviana
Ilea, Ciprian
A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota
title A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota
title_full A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota
title_fullStr A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota
title_full_unstemmed A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota
title_short A Narrative Review Discussing Vasectomy-Related Impact upon the Status of Oxidative Stress and Inflammation Biomarkers and Semen Microbiota
title_sort narrative review discussing vasectomy-related impact upon the status of oxidative stress and inflammation biomarkers and semen microbiota
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095584/
https://www.ncbi.nlm.nih.gov/pubmed/37048754
http://dx.doi.org/10.3390/jcm12072671
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