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Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes
The Tibetan pig is a characteristic breed of the Qinghai-Tibet Plateau with distinct physiological and meat quality attributes. The liver lipid profile can offer an important perspective to explore the uniqueness of Tibetan pigs. A quantitative comparison of liver lipidomes revealed significant diff...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095695/ https://www.ncbi.nlm.nih.gov/pubmed/37049754 http://dx.doi.org/10.3390/molecules28072991 |
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author | Luo, Wei Xu, Yisha Gu, Xuedong Zhang, Jiamin Wang, Jinqiu Geng, Fang |
author_facet | Luo, Wei Xu, Yisha Gu, Xuedong Zhang, Jiamin Wang, Jinqiu Geng, Fang |
author_sort | Luo, Wei |
collection | PubMed |
description | The Tibetan pig is a characteristic breed of the Qinghai-Tibet Plateau with distinct physiological and meat quality attributes. The liver lipid profile can offer an important perspective to explore the uniqueness of Tibetan pigs. A quantitative comparison of liver lipidomes revealed significant differences in the lipid profiles between Tibetan and Yorkshire pigs raised at different altitudes. The abundance of lipids in the livers of pigs raised at a high altitude was higher than that of pigs raised at a lower altitude, whereas the abundance of lipids in the livers of Yorkshire pigs was higher than that of Tibetan pigs raised at the same altitude. Of the 1101 lipids identified, 323 and 193 differentially abundant lipids (DALs) were identified in the pairwise comparisons of Tibetan and Yorkshire pigs raised at different altitudes, respectively. The DALs of Tibetan pigs consisted mainly of 161 triglycerides, along with several acylcarnitines, represented by carnitine C2:0, and significant changes in the abundance of some phospholipids. The DALs of Yorkshire pigs were more complex, with significant increases in the abundance of triglycerides, cholesteryl esters, and free fatty acids, and decreases in the abundance of some phospholipids. This research provides strong theoretical and data support for the high-quality development of the highland livestock industry. |
format | Online Article Text |
id | pubmed-10095695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100956952023-04-13 Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes Luo, Wei Xu, Yisha Gu, Xuedong Zhang, Jiamin Wang, Jinqiu Geng, Fang Molecules Article The Tibetan pig is a characteristic breed of the Qinghai-Tibet Plateau with distinct physiological and meat quality attributes. The liver lipid profile can offer an important perspective to explore the uniqueness of Tibetan pigs. A quantitative comparison of liver lipidomes revealed significant differences in the lipid profiles between Tibetan and Yorkshire pigs raised at different altitudes. The abundance of lipids in the livers of pigs raised at a high altitude was higher than that of pigs raised at a lower altitude, whereas the abundance of lipids in the livers of Yorkshire pigs was higher than that of Tibetan pigs raised at the same altitude. Of the 1101 lipids identified, 323 and 193 differentially abundant lipids (DALs) were identified in the pairwise comparisons of Tibetan and Yorkshire pigs raised at different altitudes, respectively. The DALs of Tibetan pigs consisted mainly of 161 triglycerides, along with several acylcarnitines, represented by carnitine C2:0, and significant changes in the abundance of some phospholipids. The DALs of Yorkshire pigs were more complex, with significant increases in the abundance of triglycerides, cholesteryl esters, and free fatty acids, and decreases in the abundance of some phospholipids. This research provides strong theoretical and data support for the high-quality development of the highland livestock industry. MDPI 2023-03-27 /pmc/articles/PMC10095695/ /pubmed/37049754 http://dx.doi.org/10.3390/molecules28072991 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Luo, Wei Xu, Yisha Gu, Xuedong Zhang, Jiamin Wang, Jinqiu Geng, Fang Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes |
title | Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes |
title_full | Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes |
title_fullStr | Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes |
title_full_unstemmed | Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes |
title_short | Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes |
title_sort | divergence of liver lipidomes in tibetan and yorkshire pigs living at different altitudes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095695/ https://www.ncbi.nlm.nih.gov/pubmed/37049754 http://dx.doi.org/10.3390/molecules28072991 |
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