Visible Light-Induced Cascade Sulfonylation/Cyclization to Produce Quinoline-2,4-Diones under Metal-Free Conditions

A general visible light-induced sulfonylation/cyclization to produce quinoline-2,4-diones was achieved under photocatalyst-free conditions. The reactions were performed at room temperature, and various substituents (halogen, alkyl, aryl) and substituted products were obtained with 29 examples within...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Qiu, Ge, Liu, Fei, Zhao, Dongyang, Tian, Miao, Sun, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095780/
https://www.ncbi.nlm.nih.gov/pubmed/37049899
http://dx.doi.org/10.3390/molecules28073137
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author Zhang, Yan
Qiu, Ge
Liu, Fei
Zhao, Dongyang
Tian, Miao
Sun, Kai
author_facet Zhang, Yan
Qiu, Ge
Liu, Fei
Zhao, Dongyang
Tian, Miao
Sun, Kai
author_sort Zhang, Yan
collection PubMed
description A general visible light-induced sulfonylation/cyclization to produce quinoline-2,4-diones was achieved under photocatalyst-free conditions. The reactions were performed at room temperature, and various substituents (halogen, alkyl, aryl) and substituted products were obtained with 29 examples within 2 h. Large-scale synthesis and derivatization study via carbonyl reduction to produce easily modified hydroxyl groups and convenient N-Ts deprotection showed the potential utility of this strategy.
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spelling pubmed-100957802023-04-13 Visible Light-Induced Cascade Sulfonylation/Cyclization to Produce Quinoline-2,4-Diones under Metal-Free Conditions Zhang, Yan Qiu, Ge Liu, Fei Zhao, Dongyang Tian, Miao Sun, Kai Molecules Article A general visible light-induced sulfonylation/cyclization to produce quinoline-2,4-diones was achieved under photocatalyst-free conditions. The reactions were performed at room temperature, and various substituents (halogen, alkyl, aryl) and substituted products were obtained with 29 examples within 2 h. Large-scale synthesis and derivatization study via carbonyl reduction to produce easily modified hydroxyl groups and convenient N-Ts deprotection showed the potential utility of this strategy. MDPI 2023-03-31 /pmc/articles/PMC10095780/ /pubmed/37049899 http://dx.doi.org/10.3390/molecules28073137 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yan
Qiu, Ge
Liu, Fei
Zhao, Dongyang
Tian, Miao
Sun, Kai
Visible Light-Induced Cascade Sulfonylation/Cyclization to Produce Quinoline-2,4-Diones under Metal-Free Conditions
title Visible Light-Induced Cascade Sulfonylation/Cyclization to Produce Quinoline-2,4-Diones under Metal-Free Conditions
title_full Visible Light-Induced Cascade Sulfonylation/Cyclization to Produce Quinoline-2,4-Diones under Metal-Free Conditions
title_fullStr Visible Light-Induced Cascade Sulfonylation/Cyclization to Produce Quinoline-2,4-Diones under Metal-Free Conditions
title_full_unstemmed Visible Light-Induced Cascade Sulfonylation/Cyclization to Produce Quinoline-2,4-Diones under Metal-Free Conditions
title_short Visible Light-Induced Cascade Sulfonylation/Cyclization to Produce Quinoline-2,4-Diones under Metal-Free Conditions
title_sort visible light-induced cascade sulfonylation/cyclization to produce quinoline-2,4-diones under metal-free conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095780/
https://www.ncbi.nlm.nih.gov/pubmed/37049899
http://dx.doi.org/10.3390/molecules28073137
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