4,5-Dihydro-5-Oxo-Pyrazolo[1,5-a]Thieno[2,3-c]Pyrimidine: A Novel Scaffold Containing Thiophene Ring. Chemical Reactivity and In Silico Studies to Predict the Profile to GABA(A) Receptor Subtype

The isosteric replacement of the benzene with thiophene ring is a chemical modification widely applied in medicinal chemistry. Several drugs containing the thiophene ring are marketed for treating various pathologies (osteoporosis, peripheral artery disorder, psychosis, anxiety and convulsion). Taki...

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Detalles Bibliográficos
Autores principales: Crocetti, Letizia, Guerrini, Gabriella, Melani, Fabrizio, Vergelli, Claudia, Giovannoni, Maria Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095790/
https://www.ncbi.nlm.nih.gov/pubmed/37049816
http://dx.doi.org/10.3390/molecules28073054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095790/
https://www.ncbi.nlm.nih.gov/pubmed/37049816
http://dx.doi.org/10.3390/molecules28073054

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