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In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys

Due to the unique functional properties of shape memory alloys (SMAs) and current scientific interest in Cu-containing biomaterials, a continuously cast Cu-Al-Ni alloy in the form of rods has been investigated as a potential candidate for biomedical application. Additionally, the fact that Cu- compl...

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Autores principales: Lazić, Minja Miličić, Lazić, Marko, Milašin, Jelena, Popović, Danica, Majerič, Peter, Rudolf, Rebeka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095799/
https://www.ncbi.nlm.nih.gov/pubmed/37049144
http://dx.doi.org/10.3390/ma16072851
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author Lazić, Minja Miličić
Lazić, Marko
Milašin, Jelena
Popović, Danica
Majerič, Peter
Rudolf, Rebeka
author_facet Lazić, Minja Miličić
Lazić, Marko
Milašin, Jelena
Popović, Danica
Majerič, Peter
Rudolf, Rebeka
author_sort Lazić, Minja Miličić
collection PubMed
description Due to the unique functional properties of shape memory alloys (SMAs) and current scientific interest in Cu-containing biomaterials, a continuously cast Cu-Al-Ni alloy in the form of rods has been investigated as a potential candidate for biomedical application. Additionally, the fact that Cu- complexes have an antitumour effect served as a cornerstone to develop more efficient drugs based on trace element complexes. In line with that, our study aimed to analyse the basic properties of the Cu-Al-Ni alloy, along with its anticancer properties. The detailed chemical analysis of the Cu-Al-Ni alloy was performed using XRF and SEM/EDX analyses. Furthermore, a microstructural and structure investigation was carried out, combined with hardness measurements using the static Vickers method. Observations have shown that the Cu-Al-Ni microstructure is homogeneous, with the presence of typical martensitic laths. XRD analysis confirmed the presence of two phases, β′ (monoclinic) and γ′ (orthorhombic). The viability of osteosarcoma cells in contact with the Cu-Al-Ni alloy was evaluated using epifluorescence microscopy, while their morphology and attachment pattern were observed and analysed using a high-resolution SEM microscope. Biocompatibility testing showed that the Cu-Al-Ni alloy exerted a considerable antineoplastic effect.
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spelling pubmed-100957992023-04-13 In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys Lazić, Minja Miličić Lazić, Marko Milašin, Jelena Popović, Danica Majerič, Peter Rudolf, Rebeka Materials (Basel) Article Due to the unique functional properties of shape memory alloys (SMAs) and current scientific interest in Cu-containing biomaterials, a continuously cast Cu-Al-Ni alloy in the form of rods has been investigated as a potential candidate for biomedical application. Additionally, the fact that Cu- complexes have an antitumour effect served as a cornerstone to develop more efficient drugs based on trace element complexes. In line with that, our study aimed to analyse the basic properties of the Cu-Al-Ni alloy, along with its anticancer properties. The detailed chemical analysis of the Cu-Al-Ni alloy was performed using XRF and SEM/EDX analyses. Furthermore, a microstructural and structure investigation was carried out, combined with hardness measurements using the static Vickers method. Observations have shown that the Cu-Al-Ni microstructure is homogeneous, with the presence of typical martensitic laths. XRD analysis confirmed the presence of two phases, β′ (monoclinic) and γ′ (orthorhombic). The viability of osteosarcoma cells in contact with the Cu-Al-Ni alloy was evaluated using epifluorescence microscopy, while their morphology and attachment pattern were observed and analysed using a high-resolution SEM microscope. Biocompatibility testing showed that the Cu-Al-Ni alloy exerted a considerable antineoplastic effect. MDPI 2023-04-03 /pmc/articles/PMC10095799/ /pubmed/37049144 http://dx.doi.org/10.3390/ma16072851 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lazić, Minja Miličić
Lazić, Marko
Milašin, Jelena
Popović, Danica
Majerič, Peter
Rudolf, Rebeka
In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys
title In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys
title_full In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys
title_fullStr In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys
title_full_unstemmed In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys
title_short In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys
title_sort in vitro evaluation of the potential anticancer properties of cu-based shape memory alloys
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095799/
https://www.ncbi.nlm.nih.gov/pubmed/37049144
http://dx.doi.org/10.3390/ma16072851
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