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Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy

Cancer is one of the deadliest diseases, having spurred researchers to explore effective therapeutic strategies for several centuries. Although efficacious, conventional chemotherapy usually introduces various side effects, such as cytotoxicity or multi−drug resistance. In recent decades, nanomateri...

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Detalles Bibliográficos
Autores principales: Yu, Qian, Shi, Wenhui, Li, Shun, Liu, Hong, Zhang, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095813/
https://www.ncbi.nlm.nih.gov/pubmed/37049933
http://dx.doi.org/10.3390/molecules28073170
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author Yu, Qian
Shi, Wenhui
Li, Shun
Liu, Hong
Zhang, Jianming
author_facet Yu, Qian
Shi, Wenhui
Li, Shun
Liu, Hong
Zhang, Jianming
author_sort Yu, Qian
collection PubMed
description Cancer is one of the deadliest diseases, having spurred researchers to explore effective therapeutic strategies for several centuries. Although efficacious, conventional chemotherapy usually introduces various side effects, such as cytotoxicity or multi−drug resistance. In recent decades, nanomaterials, possessing unique physical and chemical properties, have been used for the treatment of a wide range of cancers. Dynamic therapies, which can kill target cells using reactive oxygen species (ROS), are promising for tumor treatment, as they overcome the drawbacks of chemotherapy methods. Piezoelectric nanomaterials, featuring a unique property to convert ultrasound vibration energy into electrical energy, have also attracted increasing attention in biomedical research, as the piezoelectric effect can drive chemical reactions to generate ROS, leading to the newly emerging technique of ultrasound−driven tumor therapy. Piezoelectric materials are expected to bring a better solution for efficient and safe cancer treatment, as well as patient pain relief. In this review article, we highlight the most recent achievements of piezoelectric biomaterials for tumor therapy, including the mechanism of piezoelectric catalysis, conventional piezoelectric materials, modified piezoelectric materials and multifunctional piezoelectric materials for tumor treatment.
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spelling pubmed-100958132023-04-13 Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy Yu, Qian Shi, Wenhui Li, Shun Liu, Hong Zhang, Jianming Molecules Review Cancer is one of the deadliest diseases, having spurred researchers to explore effective therapeutic strategies for several centuries. Although efficacious, conventional chemotherapy usually introduces various side effects, such as cytotoxicity or multi−drug resistance. In recent decades, nanomaterials, possessing unique physical and chemical properties, have been used for the treatment of a wide range of cancers. Dynamic therapies, which can kill target cells using reactive oxygen species (ROS), are promising for tumor treatment, as they overcome the drawbacks of chemotherapy methods. Piezoelectric nanomaterials, featuring a unique property to convert ultrasound vibration energy into electrical energy, have also attracted increasing attention in biomedical research, as the piezoelectric effect can drive chemical reactions to generate ROS, leading to the newly emerging technique of ultrasound−driven tumor therapy. Piezoelectric materials are expected to bring a better solution for efficient and safe cancer treatment, as well as patient pain relief. In this review article, we highlight the most recent achievements of piezoelectric biomaterials for tumor therapy, including the mechanism of piezoelectric catalysis, conventional piezoelectric materials, modified piezoelectric materials and multifunctional piezoelectric materials for tumor treatment. MDPI 2023-04-02 /pmc/articles/PMC10095813/ /pubmed/37049933 http://dx.doi.org/10.3390/molecules28073170 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yu, Qian
Shi, Wenhui
Li, Shun
Liu, Hong
Zhang, Jianming
Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy
title Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy
title_full Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy
title_fullStr Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy
title_full_unstemmed Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy
title_short Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy
title_sort emerging advancements in piezoelectric nanomaterials for dynamic tumor therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095813/
https://www.ncbi.nlm.nih.gov/pubmed/37049933
http://dx.doi.org/10.3390/molecules28073170
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