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Selenium Enrichment of the Edible Medicinal Mushroom Antrodia camphorata by Submerged Fermentation

Selenium (Se) is an essential nutrient element in human physiological metabolism and immune function. Supplementation of bioavailable Se will confer benefit on human life, especially when intake of this nutrient is inadequate. The edible and medicinal mushroom Antrodia camphorata is a unique fungus...

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Detalles Bibliográficos
Autores principales: Li, Jin, Wen, Sai, Zhang, Baoyuan, Wang, Fenghuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095838/
https://www.ncbi.nlm.nih.gov/pubmed/37049798
http://dx.doi.org/10.3390/molecules28073036
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author Li, Jin
Wen, Sai
Zhang, Baoyuan
Wang, Fenghuan
author_facet Li, Jin
Wen, Sai
Zhang, Baoyuan
Wang, Fenghuan
author_sort Li, Jin
collection PubMed
description Selenium (Se) is an essential nutrient element in human physiological metabolism and immune function. Supplementation of bioavailable Se will confer benefit on human life, especially when intake of this nutrient is inadequate. The edible and medicinal mushroom Antrodia camphorata is a unique fungus endemic to Taiwan, which has shown high therapeutic and nutritive value. This study is the first to demonstrate that A. camphorata can assimilate and transform sodium selenite into organic selenium. With an initial concentration of Se (IV) at 10 mg/L in 100 mL of the medium at 25 °C, the total selenium content in Se-enriched A. camphorata mycelia was 1281.3 ± 79.2 µg/g, in which the organic selenium content accounted for 88.1%. Further analysis demonstrated that selenium-enriched polysaccharide was the main form of Se present in A. camphorata (61.5% of the organic selenium). Four water-soluble Se-polysaccharide fractions were separated from A. camphorata, and ACP II was the major fraction of Se-polysaccharide. The scavenging efficiency of Se-polysaccharides on DPPH and ABTS radicals was determined, proving that selenium enrichment dramatically improved the in vitro antioxidant capacity of A. camphorata polysaccharide. Therefore, the selenium accumulation and transformation ability of A. camphorata provides an opportunity for developing this beneficent fungus into a novel selenium-enriched dietary or medicinal supplement.
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spelling pubmed-100958382023-04-13 Selenium Enrichment of the Edible Medicinal Mushroom Antrodia camphorata by Submerged Fermentation Li, Jin Wen, Sai Zhang, Baoyuan Wang, Fenghuan Molecules Article Selenium (Se) is an essential nutrient element in human physiological metabolism and immune function. Supplementation of bioavailable Se will confer benefit on human life, especially when intake of this nutrient is inadequate. The edible and medicinal mushroom Antrodia camphorata is a unique fungus endemic to Taiwan, which has shown high therapeutic and nutritive value. This study is the first to demonstrate that A. camphorata can assimilate and transform sodium selenite into organic selenium. With an initial concentration of Se (IV) at 10 mg/L in 100 mL of the medium at 25 °C, the total selenium content in Se-enriched A. camphorata mycelia was 1281.3 ± 79.2 µg/g, in which the organic selenium content accounted for 88.1%. Further analysis demonstrated that selenium-enriched polysaccharide was the main form of Se present in A. camphorata (61.5% of the organic selenium). Four water-soluble Se-polysaccharide fractions were separated from A. camphorata, and ACP II was the major fraction of Se-polysaccharide. The scavenging efficiency of Se-polysaccharides on DPPH and ABTS radicals was determined, proving that selenium enrichment dramatically improved the in vitro antioxidant capacity of A. camphorata polysaccharide. Therefore, the selenium accumulation and transformation ability of A. camphorata provides an opportunity for developing this beneficent fungus into a novel selenium-enriched dietary or medicinal supplement. MDPI 2023-03-29 /pmc/articles/PMC10095838/ /pubmed/37049798 http://dx.doi.org/10.3390/molecules28073036 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Jin
Wen, Sai
Zhang, Baoyuan
Wang, Fenghuan
Selenium Enrichment of the Edible Medicinal Mushroom Antrodia camphorata by Submerged Fermentation
title Selenium Enrichment of the Edible Medicinal Mushroom Antrodia camphorata by Submerged Fermentation
title_full Selenium Enrichment of the Edible Medicinal Mushroom Antrodia camphorata by Submerged Fermentation
title_fullStr Selenium Enrichment of the Edible Medicinal Mushroom Antrodia camphorata by Submerged Fermentation
title_full_unstemmed Selenium Enrichment of the Edible Medicinal Mushroom Antrodia camphorata by Submerged Fermentation
title_short Selenium Enrichment of the Edible Medicinal Mushroom Antrodia camphorata by Submerged Fermentation
title_sort selenium enrichment of the edible medicinal mushroom antrodia camphorata by submerged fermentation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095838/
https://www.ncbi.nlm.nih.gov/pubmed/37049798
http://dx.doi.org/10.3390/molecules28073036
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