Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti

Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including (1)H-(15)N HSQC, (1)H-(15)N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole...

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Detalles Bibliográficos
Autores principales: Di, Xiaxia, Hardardottir, Ingibjorg, Freysdottir, Jona, Wang, Dongdong, Gustafson, Kirk R., Omarsdottir, Sesselja, Molinski, Tadeusz F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095911/
https://www.ncbi.nlm.nih.gov/pubmed/37049700
http://dx.doi.org/10.3390/molecules28072937
Descripción
Sumario:Geobarrettin D (1), a new bromoindole alkaloid, was isolated from the marine sponge Geodia barretti collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including (1)H-(15)N HSQC, (1)H-(15)N HMBC spectra), as well as HRESIMS data. Geobarrettin D (1) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D (1) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound 1 shows anti-inflammatory activity.

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