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Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality
Atropisomers are fascinating objects of study by themselves for chemists but also find applications in various sub-fields of applied chemistry. Obtaining them in enantiopure form is far from being a solved challenge, and the past decades has seen a surge of methodological developments in that direct...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095918/ https://www.ncbi.nlm.nih.gov/pubmed/37049905 http://dx.doi.org/10.3390/molecules28073142 |
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author | Lemaitre, Clément Perulli, Stefania Quinonero, Ophélie Bressy, Cyril Rodriguez, Jean Constantieux, Thierry García Mancheño, Olga Bugaut, Xavier |
author_facet | Lemaitre, Clément Perulli, Stefania Quinonero, Ophélie Bressy, Cyril Rodriguez, Jean Constantieux, Thierry García Mancheño, Olga Bugaut, Xavier |
author_sort | Lemaitre, Clément |
collection | PubMed |
description | Atropisomers are fascinating objects of study by themselves for chemists but also find applications in various sub-fields of applied chemistry. Obtaining them in enantiopure form is far from being a solved challenge, and the past decades has seen a surge of methodological developments in that direction. Among these strategies, oxidative aromatization with central-to-axial conversion of chirality has gained increasing popularity. It consists of the oxidation of a cyclic non-aromatic precursors into the corresponding aromatic atropisomers. This review proposes a critical analysis of this research field by delineating it and discussing its historical background and its present state of the art to draw potential future development directions. |
format | Online Article Text |
id | pubmed-10095918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100959182023-04-13 Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality Lemaitre, Clément Perulli, Stefania Quinonero, Ophélie Bressy, Cyril Rodriguez, Jean Constantieux, Thierry García Mancheño, Olga Bugaut, Xavier Molecules Review Atropisomers are fascinating objects of study by themselves for chemists but also find applications in various sub-fields of applied chemistry. Obtaining them in enantiopure form is far from being a solved challenge, and the past decades has seen a surge of methodological developments in that direction. Among these strategies, oxidative aromatization with central-to-axial conversion of chirality has gained increasing popularity. It consists of the oxidation of a cyclic non-aromatic precursors into the corresponding aromatic atropisomers. This review proposes a critical analysis of this research field by delineating it and discussing its historical background and its present state of the art to draw potential future development directions. MDPI 2023-03-31 /pmc/articles/PMC10095918/ /pubmed/37049905 http://dx.doi.org/10.3390/molecules28073142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lemaitre, Clément Perulli, Stefania Quinonero, Ophélie Bressy, Cyril Rodriguez, Jean Constantieux, Thierry García Mancheño, Olga Bugaut, Xavier Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality |
title | Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality |
title_full | Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality |
title_fullStr | Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality |
title_full_unstemmed | Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality |
title_short | Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality |
title_sort | enantioselective synthesis of atropisomers by oxidative aromatization with central-to-axial conversion of chirality |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095918/ https://www.ncbi.nlm.nih.gov/pubmed/37049905 http://dx.doi.org/10.3390/molecules28073142 |
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