Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

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PLK1 is a protein kinase that regulates mitosis and is both an important oncology drug target and a potential antitarget of drugs for the DNA damage response pathway or anti-infective host kinases. To expand the range of live cell NanoBRET target engagement assays to include PLK1, we developed an en...

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Detalles Bibliográficos
Autores principales: Yang, Xuan, Smith, Jeffery L., Beck, Michael T., Wilkinson, Jennifer M., Michaud, Ani, Vasta, James D., Robers, Matthew B., Willson, Timothy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10095950/
https://www.ncbi.nlm.nih.gov/pubmed/37049713
http://dx.doi.org/10.3390/molecules28072950

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