Site-Selective Incorporation of a Functional Group into Lys175 in the Vicinity of the Active Site of Chymotrypsin by Using Peptidyl α-Aminoalkylphosphonate Diphenyl Ester-Derivatives

We previously reported that Lys175 in the region of the active site of chymotrypsin (Csin) could be site-selectively modified by using an N-hydroxy succinimide (NHS) ester of the peptidyl derivative containing 1-amino-2-ethylphenylphosphonate diphenyl ester [NHS-Suc-Ala-Ala-Phe(P)(OPh)(2)]. In this...

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Detalles Bibliográficos
Autores principales: Ono, Shin, Koga, Masato, Arimura, Yuya, Hatakeyama, Takahiro, Kobayashi, Mai, Sagara, Jun-ichi, Nakai, Takahiko, Horino, Yoshikazu, Kuroda, Hirofumi, Oyama, Hiroshi, Arima, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096113/
https://www.ncbi.nlm.nih.gov/pubmed/37049913
http://dx.doi.org/10.3390/molecules28073150

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