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A D-2-hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development

In humans, mutations in D-2-hydroxyglutarate (D-2HG) dehydrogenase (D2HGDH) result in D-2HG accumulation, delayed development, seizures, and ataxia. While the mechanisms of 2HG-associated diseases have been studied extensively, the endogenous metabolism of D-2HG remains unclear in any organism. Here...

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Detalles Bibliográficos
Autores principales:	Ponomarova, Olga, Zhang, Hefei, Li, Xuhang, Nanda, Shivani, Leland, Thomas B., Fox, Bennett W., Starbard, Alyxandra N., Giese, Gabrielle E., Schroeder, Frank C., Yilmaz, L. Safak, Walhout, Albertha J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Short Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096224/ https://www.ncbi.nlm.nih.gov/pubmed/37043428 http://dx.doi.org/10.1371/journal.pbio.3002057

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