Predicting activatory and inhibitory drug–target interactions based on structural compound representations and genetically perturbed transcriptomes

A computational approach to identifying drug–target interactions (DTIs) is a credible strategy for accelerating drug development and understanding the mechanisms of action of small molecules. However, current methods to predict DTIs have mainly focused on identifying simple interactions, requiring f...

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Detalles Bibliográficos
Autores principales: Lee, Won-Yung, Lee, Choong-Yeol, Kim, Chang-Eop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096289/
https://www.ncbi.nlm.nih.gov/pubmed/37043429
http://dx.doi.org/10.1371/journal.pone.0282042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096289/
https://www.ncbi.nlm.nih.gov/pubmed/37043429
http://dx.doi.org/10.1371/journal.pone.0282042

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