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Silencing of dentate gyrus inhibits mossy fiber sprouting and prevents epileptogenesis through NDR2 kinase in pentylenetetrazole kindling rat model of TLE

Epileptogenesis is a potential process. Mossy fiber sprouting (MFS) contributes to epileptogenesis. Silencing of the dentate gyrus (DG) suppressed spontaneous seizures model of epilepsy and hyperactivity of granule cells resulted in MFS in vitro. However, the role of DG’s excitability in epileptogen...

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Detalles Bibliográficos
Autores principales:	Zhang, Chen, He, Zixian, Tan, Zheren, Tian, Fafa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096303/ https://www.ncbi.nlm.nih.gov/pubmed/37043471 http://dx.doi.org/10.1371/journal.pone.0284359

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