In silico analysis of ACE2 from different animal species provides new insights into SARS-CoV-2 species spillover

Aim: This study aimed to analyze the phylogenetic relationships between the ACE2 of humans and other animals and investigate the potential interaction between SARS-CoV-2 RBD and ACE2 of different species. Materials & methods: The phylogenetic construction and molecular interactions were assessed...

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Detalles Bibliográficos
Autores principales: Mesquita, Felipe Pantoja, Noronha Souza, Pedro Filho, Aragão, Dyane Rocha, Diógenes, Expedito Maia, da Silva, Emerson Lucena, Amaral, Jackson Lima, Freire, Valder Nogueira, de Souza Collares Maia Castelo-Branco, Débora, Montenegro, Raquel Carvalho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096339/
https://www.ncbi.nlm.nih.gov/pubmed/37064326
http://dx.doi.org/10.2217/fvl-2022-0187
Descripción
Sumario:Aim: This study aimed to analyze the phylogenetic relationships between the ACE2 of humans and other animals and investigate the potential interaction between SARS-CoV-2 RBD and ACE2 of different species. Materials & methods: The phylogenetic construction and molecular interactions were assessed using computational models. Results & conclusion: Despite the evolutionary distance, 11 species had a perfect fit for the interaction between their ACE2 and SARS-CoV-2 RBD (Chinchilla lanigera, Neovison vison, Rhinolophus sinicus, Emballonura alecto, Saccopteryx bilineata, Numida meleagris). Among them, the avian N. meleagris was reported for the first time in this study as a probable SARS-CoV-2 host due to the strong molecular interactions. Therefore, predicting potential hosts for SARS-CoV-2 for understanding the epidemiological cycle and proposal of surveillance strategies.

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