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Discovery of N,4-Di(1H-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation

Cyclin-dependent kinase 2 (CDK2) has been garnering considerable interest as a target to develop new cancer treatments and to ameliorate resistance to CDK4/6 inhibitors. However, a selective CDK2 inhibitor has yet to be clinically approved. With the desire to discover novel, potent, and selective CD...

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Detalles Bibliográficos
Autores principales:	Fanta, Biruk Sintayehu, Lenjisa, Jimma, Teo, Theodosia, Kou, Lianmeng, Mekonnen, Laychiluh, Yang, Yuchao, Basnet, Sunita K. C., Hassankhani, Ramin, Sykes, Matthew J., Yu, Mingfeng, Wang, Shudong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096391/ https://www.ncbi.nlm.nih.gov/pubmed/37049714 http://dx.doi.org/10.3390/molecules28072951

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