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The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats
The aim of this study was to investigate the potential protective effects of walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats. The rats were divided into the following groups: normal group, model group, omeprazole group (0.02 g/kg), and WOPs groups (0.22, 0.44, and 0.88 g/k...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096596/ https://www.ncbi.nlm.nih.gov/pubmed/37049515 http://dx.doi.org/10.3390/nu15071675 |
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author | Liu, Rui Zhu, Na Hao, Yuntao Liu, Xinran Kang, Jiawei Mao, Ruixue Yu, Xiaochen Li, Yong |
author_facet | Liu, Rui Zhu, Na Hao, Yuntao Liu, Xinran Kang, Jiawei Mao, Ruixue Yu, Xiaochen Li, Yong |
author_sort | Liu, Rui |
collection | PubMed |
description | The aim of this study was to investigate the potential protective effects of walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats. The rats were divided into the following groups: normal group, model group, omeprazole group (0.02 g/kg), and WOPs groups (0.22, 0.44, and 0.88 g/kg, respectively). After receiving gavage once per day for 30 consecutive days, the rats were injected intraperitoneally with indomethacin 48 mg/kg to induce gastric ulcers. Then, the serum inflammatory cytokines and gastric prostaglandin E2 (PGE2), oxidative stress-related indicators, and the RNA expression of COX-1 and COX-2 were measured. The results revealed that WOPs confer significant gastroprotection on gastric ulcers caused by indomethacin, regulating inflammatory cytokines, oxidative stress, and prostaglandins synthesis, and enhancing the expression of COX-1 and COX-2 in gastric tissue, thus exerting its protective effect on gastric mucosa. The gastroprotective mechanism may be related to the involvement of the arachidonic acid metabolism and upregulation of tryptophan, phenylalanine, tyrosine, and alpha-Linolenic acid metabolism synthesis in vivo. |
format | Online Article Text |
id | pubmed-10096596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100965962023-04-13 The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats Liu, Rui Zhu, Na Hao, Yuntao Liu, Xinran Kang, Jiawei Mao, Ruixue Yu, Xiaochen Li, Yong Nutrients Article The aim of this study was to investigate the potential protective effects of walnut oligopeptides (WOPs) on indomethacin-induced gastric ulcers in rats. The rats were divided into the following groups: normal group, model group, omeprazole group (0.02 g/kg), and WOPs groups (0.22, 0.44, and 0.88 g/kg, respectively). After receiving gavage once per day for 30 consecutive days, the rats were injected intraperitoneally with indomethacin 48 mg/kg to induce gastric ulcers. Then, the serum inflammatory cytokines and gastric prostaglandin E2 (PGE2), oxidative stress-related indicators, and the RNA expression of COX-1 and COX-2 were measured. The results revealed that WOPs confer significant gastroprotection on gastric ulcers caused by indomethacin, regulating inflammatory cytokines, oxidative stress, and prostaglandins synthesis, and enhancing the expression of COX-1 and COX-2 in gastric tissue, thus exerting its protective effect on gastric mucosa. The gastroprotective mechanism may be related to the involvement of the arachidonic acid metabolism and upregulation of tryptophan, phenylalanine, tyrosine, and alpha-Linolenic acid metabolism synthesis in vivo. MDPI 2023-03-30 /pmc/articles/PMC10096596/ /pubmed/37049515 http://dx.doi.org/10.3390/nu15071675 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Rui Zhu, Na Hao, Yuntao Liu, Xinran Kang, Jiawei Mao, Ruixue Yu, Xiaochen Li, Yong The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats |
title | The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats |
title_full | The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats |
title_fullStr | The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats |
title_full_unstemmed | The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats |
title_short | The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats |
title_sort | protective effect of walnut oligopeptides against indomethacin-induced gastric ulcer in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096596/ https://www.ncbi.nlm.nih.gov/pubmed/37049515 http://dx.doi.org/10.3390/nu15071675 |
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