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Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases

The inadequate dietary intake of Vitamin D and Vitamin K is an easily reversible factor favoring IBD-associated bone loss, but data on Vitamin K are lacking. A 28-item quantitative food frequency questionnaire was administered to 193 IBD patients (89 Crohn’s disease and 104 ulcerative colitis), and...

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Autores principales: Vernia, Filippo, Burrelli Scotti, Giorgia, Bertetti, Noemi Sara, Donato, Giuseppe, Necozione, Stefano, Vernia, Piero, Pallotta, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096607/
https://www.ncbi.nlm.nih.gov/pubmed/37049518
http://dx.doi.org/10.3390/nu15071678
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author Vernia, Filippo
Burrelli Scotti, Giorgia
Bertetti, Noemi Sara
Donato, Giuseppe
Necozione, Stefano
Vernia, Piero
Pallotta, Nadia
author_facet Vernia, Filippo
Burrelli Scotti, Giorgia
Bertetti, Noemi Sara
Donato, Giuseppe
Necozione, Stefano
Vernia, Piero
Pallotta, Nadia
author_sort Vernia, Filippo
collection PubMed
description The inadequate dietary intake of Vitamin D and Vitamin K is an easily reversible factor favoring IBD-associated bone loss, but data on Vitamin K are lacking. A 28-item quantitative food frequency questionnaire was administered to 193 IBD patients (89 Crohn’s disease and 104 ulcerative colitis), and 199 controls. Patients’ demographics, clinical and laboratory findings were analyzed in relation to recommended daily allowances. VitD intake was inadequate both in the IBD and control patients (8.3 ± 4.5 µg/day in IBD, 53.1% RDA, and 9.7 ± 5.9 µg/day, 63.2% RDA, respectively). Conversely, the mean ViK intake was less than adequate in IBD, at 116.7 ± 116.3 µg/day (78.7% RDA), and high in controls, at 203.1 ± 166.9 µg/day (138.8% RDA). Nonetheless, due to marked inter-individual differences, diets were severely lacking VitK in 40% of UC and 49% of CD patients, more so in females and those with active disease. The intake of Vit D was non-significantly lower in colitis than that in Crohn’s disease (7.9 vs. 8.7 µg/day). The opposite was observed for VitK (123.5 vs. 107.0 µg/day). Thus, the diet lacks the micronutrients involved in bone wellbeing in a large proportion of IBD patients. While VitD supplementation is the rule, VitK shortages need proactive nutritional intervention.
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spelling pubmed-100966072023-04-13 Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases Vernia, Filippo Burrelli Scotti, Giorgia Bertetti, Noemi Sara Donato, Giuseppe Necozione, Stefano Vernia, Piero Pallotta, Nadia Nutrients Article The inadequate dietary intake of Vitamin D and Vitamin K is an easily reversible factor favoring IBD-associated bone loss, but data on Vitamin K are lacking. A 28-item quantitative food frequency questionnaire was administered to 193 IBD patients (89 Crohn’s disease and 104 ulcerative colitis), and 199 controls. Patients’ demographics, clinical and laboratory findings were analyzed in relation to recommended daily allowances. VitD intake was inadequate both in the IBD and control patients (8.3 ± 4.5 µg/day in IBD, 53.1% RDA, and 9.7 ± 5.9 µg/day, 63.2% RDA, respectively). Conversely, the mean ViK intake was less than adequate in IBD, at 116.7 ± 116.3 µg/day (78.7% RDA), and high in controls, at 203.1 ± 166.9 µg/day (138.8% RDA). Nonetheless, due to marked inter-individual differences, diets were severely lacking VitK in 40% of UC and 49% of CD patients, more so in females and those with active disease. The intake of Vit D was non-significantly lower in colitis than that in Crohn’s disease (7.9 vs. 8.7 µg/day). The opposite was observed for VitK (123.5 vs. 107.0 µg/day). Thus, the diet lacks the micronutrients involved in bone wellbeing in a large proportion of IBD patients. While VitD supplementation is the rule, VitK shortages need proactive nutritional intervention. MDPI 2023-03-30 /pmc/articles/PMC10096607/ /pubmed/37049518 http://dx.doi.org/10.3390/nu15071678 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vernia, Filippo
Burrelli Scotti, Giorgia
Bertetti, Noemi Sara
Donato, Giuseppe
Necozione, Stefano
Vernia, Piero
Pallotta, Nadia
Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases
title Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases
title_full Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases
title_fullStr Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases
title_full_unstemmed Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases
title_short Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases
title_sort low vitamin k and vitamin d dietary intake in patients with inflammatory bowel diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096607/
https://www.ncbi.nlm.nih.gov/pubmed/37049518
http://dx.doi.org/10.3390/nu15071678
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