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A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite

A new turn-on probe (SWJT-20) based on isophorone fluorophore for the detection of nerve agent mimic diethyl chlorophosphite (DCP) was designed and synthesized. SWJT-20 could rapidly respond to DCP within 2 s using UV-Vis or fluorescent spectra, accompanied by a significant change in the solution co...

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Autores principales: Yu, Xue-Shuang, Zhu, Mao-Mei, Zuo, Rui, Peng, Yu, Wang, Ya-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096706/
https://www.ncbi.nlm.nih.gov/pubmed/37050000
http://dx.doi.org/10.3390/molecules28073237
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author Yu, Xue-Shuang
Zhu, Mao-Mei
Zuo, Rui
Peng, Yu
Wang, Ya-Wen
author_facet Yu, Xue-Shuang
Zhu, Mao-Mei
Zuo, Rui
Peng, Yu
Wang, Ya-Wen
author_sort Yu, Xue-Shuang
collection PubMed
description A new turn-on probe (SWJT-20) based on isophorone fluorophore for the detection of nerve agent mimic diethyl chlorophosphite (DCP) was designed and synthesized. SWJT-20 could rapidly respond to DCP within 2 s using UV-Vis or fluorescent spectra, accompanied by a significant change in the solution color under visible light or UV light, which could be observed by the naked eyes. The detection limit of SWJT-20 to DCP was as low as 8.3 nM, which is lower than those of most reported fluorescent probes for DCP detection. Additionally, SWJT-20 could quantitatively measure DCP using ratio changes in A(427)/A(645) in absorption spectra. Furthermore, facile paper as sensors with the visualization of colorimetric/fluorometric responses based on SWJT-20 has been fabricated. Notably, this probe could detect DCP vapor through gas diffusion experiments.
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spelling pubmed-100967062023-04-13 A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite Yu, Xue-Shuang Zhu, Mao-Mei Zuo, Rui Peng, Yu Wang, Ya-Wen Molecules Article A new turn-on probe (SWJT-20) based on isophorone fluorophore for the detection of nerve agent mimic diethyl chlorophosphite (DCP) was designed and synthesized. SWJT-20 could rapidly respond to DCP within 2 s using UV-Vis or fluorescent spectra, accompanied by a significant change in the solution color under visible light or UV light, which could be observed by the naked eyes. The detection limit of SWJT-20 to DCP was as low as 8.3 nM, which is lower than those of most reported fluorescent probes for DCP detection. Additionally, SWJT-20 could quantitatively measure DCP using ratio changes in A(427)/A(645) in absorption spectra. Furthermore, facile paper as sensors with the visualization of colorimetric/fluorometric responses based on SWJT-20 has been fabricated. Notably, this probe could detect DCP vapor through gas diffusion experiments. MDPI 2023-04-05 /pmc/articles/PMC10096706/ /pubmed/37050000 http://dx.doi.org/10.3390/molecules28073237 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Xue-Shuang
Zhu, Mao-Mei
Zuo, Rui
Peng, Yu
Wang, Ya-Wen
A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite
title A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite
title_full A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite
title_fullStr A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite
title_full_unstemmed A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite
title_short A Turn-On and Colorimetric Probe Based on Isophorone Skeleton for Detecting Nerve Agent Mimic Diethyl Chlorophosphite
title_sort turn-on and colorimetric probe based on isophorone skeleton for detecting nerve agent mimic diethyl chlorophosphite
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096706/
https://www.ncbi.nlm.nih.gov/pubmed/37050000
http://dx.doi.org/10.3390/molecules28073237
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