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Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension

Maternal nutrition has a key role in the developmental programming of adult disease. Excessive maternal fructose intake contributes to offspring hypertension. Newly discovered evidence supports the idea that early-life gut microbiota are connected to hypertension later in life. Short-chain fatty aci...

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Autores principales: Tain, You-Lin, Hou, Chih-Yao, Chang-Chien, Guo-Ping, Lin, Sufan, Tzeng, Hong-Tai, Lee, Wei-Chia, Wu, Kay L. H., Yu, Hong-Ren, Chan, Julie Y. H., Hsu, Chien-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096847/
https://www.ncbi.nlm.nih.gov/pubmed/37049522
http://dx.doi.org/10.3390/nu15071682
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author Tain, You-Lin
Hou, Chih-Yao
Chang-Chien, Guo-Ping
Lin, Sufan
Tzeng, Hong-Tai
Lee, Wei-Chia
Wu, Kay L. H.
Yu, Hong-Ren
Chan, Julie Y. H.
Hsu, Chien-Ning
author_facet Tain, You-Lin
Hou, Chih-Yao
Chang-Chien, Guo-Ping
Lin, Sufan
Tzeng, Hong-Tai
Lee, Wei-Chia
Wu, Kay L. H.
Yu, Hong-Ren
Chan, Julie Y. H.
Hsu, Chien-Ning
author_sort Tain, You-Lin
collection PubMed
description Maternal nutrition has a key role in the developmental programming of adult disease. Excessive maternal fructose intake contributes to offspring hypertension. Newly discovered evidence supports the idea that early-life gut microbiota are connected to hypertension later in life. Short-chain fatty acids (SCFAs), butyrate, and propionate are microbiota-derived metabolites, also known as postbiotics. The present study aimed to determine whether maternal butyrate or propionate supplementation can protect offspring from hypertension using a maternal high-fructose (HF) diet rat model. Female Sprague Dawley rats were allocated during pregnancy and lactation to (1) regular chow (ND); (2) 60% high-fructose diet (HF); (3) HF diet plus butyrate (HFB, 400 mg/kg/day); and (4) HF diet plus propionate (HFP, 200 mmol/L). Male offspring were sacrificed at 12 weeks of age. The maternal HF diet impaired the offspring’s BP, which was prevented by perinatal butyrate or propionate supplementation. Both butyrate and propionate treatments similarly increased plasma concentrations of propionic acid, isobutyric acid, and valeric acid in adult offspring. Butyrate supplementation had a more profound impact on trimethylamine N-oxide metabolism and nitric oxide parameters. Whilst propionate treatment mainly influenced gut microbiota composition, it directly altered the abundance of genera Anaerovorax, Lactobacillus, Macellibacteroides, and Rothia. Our results shed new light on targeting gut microbiota through the use of postbiotics to prevent maternal HF intake-primed hypertension, a finding worthy of clinical translation.
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spelling pubmed-100968472023-04-13 Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension Tain, You-Lin Hou, Chih-Yao Chang-Chien, Guo-Ping Lin, Sufan Tzeng, Hong-Tai Lee, Wei-Chia Wu, Kay L. H. Yu, Hong-Ren Chan, Julie Y. H. Hsu, Chien-Ning Nutrients Article Maternal nutrition has a key role in the developmental programming of adult disease. Excessive maternal fructose intake contributes to offspring hypertension. Newly discovered evidence supports the idea that early-life gut microbiota are connected to hypertension later in life. Short-chain fatty acids (SCFAs), butyrate, and propionate are microbiota-derived metabolites, also known as postbiotics. The present study aimed to determine whether maternal butyrate or propionate supplementation can protect offspring from hypertension using a maternal high-fructose (HF) diet rat model. Female Sprague Dawley rats were allocated during pregnancy and lactation to (1) regular chow (ND); (2) 60% high-fructose diet (HF); (3) HF diet plus butyrate (HFB, 400 mg/kg/day); and (4) HF diet plus propionate (HFP, 200 mmol/L). Male offspring were sacrificed at 12 weeks of age. The maternal HF diet impaired the offspring’s BP, which was prevented by perinatal butyrate or propionate supplementation. Both butyrate and propionate treatments similarly increased plasma concentrations of propionic acid, isobutyric acid, and valeric acid in adult offspring. Butyrate supplementation had a more profound impact on trimethylamine N-oxide metabolism and nitric oxide parameters. Whilst propionate treatment mainly influenced gut microbiota composition, it directly altered the abundance of genera Anaerovorax, Lactobacillus, Macellibacteroides, and Rothia. Our results shed new light on targeting gut microbiota through the use of postbiotics to prevent maternal HF intake-primed hypertension, a finding worthy of clinical translation. MDPI 2023-03-30 /pmc/articles/PMC10096847/ /pubmed/37049522 http://dx.doi.org/10.3390/nu15071682 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tain, You-Lin
Hou, Chih-Yao
Chang-Chien, Guo-Ping
Lin, Sufan
Tzeng, Hong-Tai
Lee, Wei-Chia
Wu, Kay L. H.
Yu, Hong-Ren
Chan, Julie Y. H.
Hsu, Chien-Ning
Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension
title Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension
title_full Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension
title_fullStr Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension
title_full_unstemmed Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension
title_short Reprogramming Effects of Postbiotic Butyrate and Propionate on Maternal High-Fructose Diet-Induced Offspring Hypertension
title_sort reprogramming effects of postbiotic butyrate and propionate on maternal high-fructose diet-induced offspring hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096847/
https://www.ncbi.nlm.nih.gov/pubmed/37049522
http://dx.doi.org/10.3390/nu15071682
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