Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination

In this longitudinal prospective cohort of healthy adults in the United States, we found that coronavirus disease 2019 messenger RNA primary series and booster vaccinations elicited high titers of broadly cross-reactive neutralizing and antibody-dependent cell-mediated cytotoxicity antibodies, which...

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Autores principales: Chen, Xuemin, Ciric, Caroline, Gibson, Theda, Anderson, Larry J, Anderson, Evan J, Rostad, Christina A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096895/
https://www.ncbi.nlm.nih.gov/pubmed/37065985
http://dx.doi.org/10.1093/ofid/ofad167
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author Chen, Xuemin
Ciric, Caroline
Gibson, Theda
Anderson, Larry J
Anderson, Evan J
Rostad, Christina A
author_facet Chen, Xuemin
Ciric, Caroline
Gibson, Theda
Anderson, Larry J
Anderson, Evan J
Rostad, Christina A
author_sort Chen, Xuemin
collection PubMed
description In this longitudinal prospective cohort of healthy adults in the United States, we found that coronavirus disease 2019 messenger RNA primary series and booster vaccinations elicited high titers of broadly cross-reactive neutralizing and antibody-dependent cell-mediated cytotoxicity antibodies, which gradually waned over 6 months, particularly against severe acute respiratory syndrome coronavirus 2 variants. These data support the indication for a subsequent booster vaccination.
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spelling pubmed-100968952023-04-13 Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination Chen, Xuemin Ciric, Caroline Gibson, Theda Anderson, Larry J Anderson, Evan J Rostad, Christina A Open Forum Infect Dis Brief Report In this longitudinal prospective cohort of healthy adults in the United States, we found that coronavirus disease 2019 messenger RNA primary series and booster vaccinations elicited high titers of broadly cross-reactive neutralizing and antibody-dependent cell-mediated cytotoxicity antibodies, which gradually waned over 6 months, particularly against severe acute respiratory syndrome coronavirus 2 variants. These data support the indication for a subsequent booster vaccination. Oxford University Press 2023-03-28 /pmc/articles/PMC10096895/ /pubmed/37065985 http://dx.doi.org/10.1093/ofid/ofad167 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Chen, Xuemin
Ciric, Caroline
Gibson, Theda
Anderson, Larry J
Anderson, Evan J
Rostad, Christina A
Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
title Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
title_full Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
title_fullStr Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
title_full_unstemmed Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
title_short Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
title_sort longitudinal neutralizing and functional antibody responses to severe acute respiratory syndrome coronavirus 2 variants following messenger rna coronavirus disease 2019 vaccination
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096895/
https://www.ncbi.nlm.nih.gov/pubmed/37065985
http://dx.doi.org/10.1093/ofid/ofad167
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