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A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema

The World Health Organisation (WHO) recommends that severe wasting and/or oedema should be treated with ready-to-use therapeutic food (RUTF) at a dose of 150–220 kcal/kg/day for 6–8 weeks. Emerging evidence suggests that variations of RUTF dosing regimens from the WHO recommendation are not inferior...

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Autores principales: Likoswe, Blessings H., Chimera-Khombe, Bernadette, Patson, Noel, Selemani, Apatsa, Potani, Isabel, Phuka, John, Maleta, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096907/
https://www.ncbi.nlm.nih.gov/pubmed/37049590
http://dx.doi.org/10.3390/nu15071750
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author Likoswe, Blessings H.
Chimera-Khombe, Bernadette
Patson, Noel
Selemani, Apatsa
Potani, Isabel
Phuka, John
Maleta, Kenneth
author_facet Likoswe, Blessings H.
Chimera-Khombe, Bernadette
Patson, Noel
Selemani, Apatsa
Potani, Isabel
Phuka, John
Maleta, Kenneth
author_sort Likoswe, Blessings H.
collection PubMed
description The World Health Organisation (WHO) recommends that severe wasting and/or oedema should be treated with ready-to-use therapeutic food (RUTF) at a dose of 150–220 kcal/kg/day for 6–8 weeks. Emerging evidence suggests that variations of RUTF dosing regimens from the WHO recommendation are not inferior. We aimed to assess the comparative efficacy and effectiveness of different RUTF doses and durations in comparison with the current WHO RUTF dose recommendation for treating severe wasting and/or oedema among 6–59-month-old children. A systematic literature search identified three studies for inclusion, and the outcomes of interest included anthropometric recovery, anthropometric measures and indices, non-response, time to recovery, readmission, sustained recovery, and mortality. The study was registered with PROSPERO, CRD 42021276757. Only three studies were eligible for analysis. There was an overall high risk of bias for two of the studies and some concerns for the third study. Overall, there were no differences between the reduced and standard RUTF dose groups in all outcomes of interest. Despite the finding of no differences between reduced and standard-dose RUTF, the studies are too few to conclusively declare that reduced RUTF dose was more efficacious than standard RUTF.
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spelling pubmed-100969072023-04-13 A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema Likoswe, Blessings H. Chimera-Khombe, Bernadette Patson, Noel Selemani, Apatsa Potani, Isabel Phuka, John Maleta, Kenneth Nutrients Review The World Health Organisation (WHO) recommends that severe wasting and/or oedema should be treated with ready-to-use therapeutic food (RUTF) at a dose of 150–220 kcal/kg/day for 6–8 weeks. Emerging evidence suggests that variations of RUTF dosing regimens from the WHO recommendation are not inferior. We aimed to assess the comparative efficacy and effectiveness of different RUTF doses and durations in comparison with the current WHO RUTF dose recommendation for treating severe wasting and/or oedema among 6–59-month-old children. A systematic literature search identified three studies for inclusion, and the outcomes of interest included anthropometric recovery, anthropometric measures and indices, non-response, time to recovery, readmission, sustained recovery, and mortality. The study was registered with PROSPERO, CRD 42021276757. Only three studies were eligible for analysis. There was an overall high risk of bias for two of the studies and some concerns for the third study. Overall, there were no differences between the reduced and standard RUTF dose groups in all outcomes of interest. Despite the finding of no differences between reduced and standard-dose RUTF, the studies are too few to conclusively declare that reduced RUTF dose was more efficacious than standard RUTF. MDPI 2023-04-03 /pmc/articles/PMC10096907/ /pubmed/37049590 http://dx.doi.org/10.3390/nu15071750 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Likoswe, Blessings H.
Chimera-Khombe, Bernadette
Patson, Noel
Selemani, Apatsa
Potani, Isabel
Phuka, John
Maleta, Kenneth
A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema
title A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema
title_full A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema
title_fullStr A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema
title_full_unstemmed A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema
title_short A Systematic Review on the Optimal Dose and Duration of Ready-to-Use Therapeutic Food (RUTF) for 6–59-Month-Old Children with Severe Wasting or Oedema
title_sort systematic review on the optimal dose and duration of ready-to-use therapeutic food (rutf) for 6–59-month-old children with severe wasting or oedema
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10096907/
https://www.ncbi.nlm.nih.gov/pubmed/37049590
http://dx.doi.org/10.3390/nu15071750
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