The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives

The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. Aβ42 was deposited as cored plaques and Aβ3...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshimura, Rikuya, Miyasaka, Tomohiro, Funamoto, Satoru, Saito, Takashi, Saido, Takaomi C., Ikegawa, Masaya, Kakuda, Nobuto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097081/
https://www.ncbi.nlm.nih.gov/pubmed/36879381
http://dx.doi.org/10.1002/brb3.2953
_version_ 1785024493764214784
author Yoshimura, Rikuya
Miyasaka, Tomohiro
Funamoto, Satoru
Saito, Takashi
Saido, Takaomi C.
Ikegawa, Masaya
Kakuda, Nobuto
author_facet Yoshimura, Rikuya
Miyasaka, Tomohiro
Funamoto, Satoru
Saito, Takashi
Saido, Takaomi C.
Ikegawa, Masaya
Kakuda, Nobuto
author_sort Yoshimura, Rikuya
collection PubMed
description The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. Aβ42 was deposited as cored plaques and Aβ38 accumulated around Aβ42.
format Online
Article
Text
id pubmed-10097081
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-100970812023-04-13 The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives Yoshimura, Rikuya Miyasaka, Tomohiro Funamoto, Satoru Saito, Takashi Saido, Takaomi C. Ikegawa, Masaya Kakuda, Nobuto Brain Behav Brief Reports The morphology of senile plaques depends on the APP knock‐in mice brain fixative. Solid forms of senile plaques were detected in APP knock‐in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. Aβ42 was deposited as cored plaques and Aβ38 accumulated around Aβ42. John Wiley and Sons Inc. 2023-03-06 /pmc/articles/PMC10097081/ /pubmed/36879381 http://dx.doi.org/10.1002/brb3.2953 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Reports
Yoshimura, Rikuya
Miyasaka, Tomohiro
Funamoto, Satoru
Saito, Takashi
Saido, Takaomi C.
Ikegawa, Masaya
Kakuda, Nobuto
The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
title The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
title_full The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
title_fullStr The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
title_full_unstemmed The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
title_short The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives
title_sort senile plaque: morphological differences in app knock‐in mice brains by fixatives
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097081/
https://www.ncbi.nlm.nih.gov/pubmed/36879381
http://dx.doi.org/10.1002/brb3.2953
work_keys_str_mv AT yoshimurarikuya thesenileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT miyasakatomohiro thesenileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT funamotosatoru thesenileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT saitotakashi thesenileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT saidotakaomic thesenileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT ikegawamasaya thesenileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT kakudanobuto thesenileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT yoshimurarikuya senileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT miyasakatomohiro senileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT funamotosatoru senileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT saitotakashi senileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT saidotakaomic senileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT ikegawamasaya senileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives
AT kakudanobuto senileplaquemorphologicaldifferencesinappknockinmicebrainsbyfixatives

Ejemplares similares