Personality traits and disorders in Alzheimer's disease

BACKGROUND: The relationships between axis II personality disorders and the normative personality traits were explored in the context of current and pre‐morbid personality assessment in Alzheimer's disease (AD). METHODS: The study was conducted with four groups who were administered the NEO‐FFI and the PDQ‐4+, in the form of individual interview sessions. Current personality measure: consisting of 44 female participants (AD group) and, the control group, consisting of 80 female participants from the population at large. Pre‐morbid personality measure: AD group informants (n = 40); control group informants (n = 42). RESULTS: The results are in line with the literature review and provide new research data. By factorial discriminant analysis, the current and pre‐morbid personality variables that differentiate AD from control groups are identified. The personality traits variables are the best discriminators such as low agreeableness, low openness to experience, and high neuroticism, suggesting that the maladaptive personality functioning can be described extending the range of psychopathology to a dimensional approach. CONCLUSIONS: The study of personality variables seems to suggest, in their inclusion, the possibility to increase sensitivity toward an assessment in AD.