Cargando…

A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates

(1) Background: We investigated, for the first time, whether dietary simple sugar intake affects MELD score changes over time in a cohort of cirrhotic liver transplant candidates. (2) Methods: the MELD score, dietary habits using a 3-day food diary, and visceral adipose tissue index (VATI) measured...

Descripción completa

Detalles Bibliográficos
Autores principales: Parisse, Simona, Carnevale, Sara, Di Bartolomeo, Francesca, Poli, Edoardo, Miceli, Francesca, Ferri, Flaminia, Mischitelli, Monica, Rocco, Bianca, Lai, Quirino, Lucatelli, Pierleone, Corona, Mario, Mennini, Gianluca, De Santis, Adriano, Rossi, Massimo, Muscaritoli, Maurizio, Cantafora, Alfredo, Ginanni Corradini, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097197/
https://www.ncbi.nlm.nih.gov/pubmed/37049416
http://dx.doi.org/10.3390/nu15071575
_version_ 1785024522209984512
author Parisse, Simona
Carnevale, Sara
Di Bartolomeo, Francesca
Poli, Edoardo
Miceli, Francesca
Ferri, Flaminia
Mischitelli, Monica
Rocco, Bianca
Lai, Quirino
Lucatelli, Pierleone
Corona, Mario
Mennini, Gianluca
De Santis, Adriano
Rossi, Massimo
Muscaritoli, Maurizio
Cantafora, Alfredo
Ginanni Corradini, Stefano
author_facet Parisse, Simona
Carnevale, Sara
Di Bartolomeo, Francesca
Poli, Edoardo
Miceli, Francesca
Ferri, Flaminia
Mischitelli, Monica
Rocco, Bianca
Lai, Quirino
Lucatelli, Pierleone
Corona, Mario
Mennini, Gianluca
De Santis, Adriano
Rossi, Massimo
Muscaritoli, Maurizio
Cantafora, Alfredo
Ginanni Corradini, Stefano
author_sort Parisse, Simona
collection PubMed
description (1) Background: We investigated, for the first time, whether dietary simple sugar intake affects MELD score changes over time in a cohort of cirrhotic liver transplant candidates. (2) Methods: the MELD score, dietary habits using a 3-day food diary, and visceral adipose tissue index (VATI) measured with CT scan were assessed in 80 consecutive outpatient cirrhotic patients at baseline, after counseling to follow current nutritional guidelines. The MELD score was reassessed after six months and the DELTA-MELD was calculated as the MELD at the second assessment minus the MELD at baseline. (3) Results: Compared with the baseline, the MELD score of cirrhotic patients at the end of the study was decreased, stable, or increased in 36%, 8% and 56% of patients, respectively. In separate multiple linear regression models, DELTA-MELD was positively and independently correlated with the daily intake of simple sugars expressed in g/kg body weight (p = 0.01) or as a percentage of total caloric intake (p = 0.0004) and with the number of daily portions of fruit, added sugar, jam, and honey (p = 0.003). These associations were present almost exclusively in patients with VATI above the median value. (4) Conclusions: In cirrhotic patients with high amounts of visceral adipose tissue the consumption of simple sugars and fructose should be limited to improve their clinical outcome.
format Online
Article
Text
id pubmed-10097197
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100971972023-04-13 A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates Parisse, Simona Carnevale, Sara Di Bartolomeo, Francesca Poli, Edoardo Miceli, Francesca Ferri, Flaminia Mischitelli, Monica Rocco, Bianca Lai, Quirino Lucatelli, Pierleone Corona, Mario Mennini, Gianluca De Santis, Adriano Rossi, Massimo Muscaritoli, Maurizio Cantafora, Alfredo Ginanni Corradini, Stefano Nutrients Article (1) Background: We investigated, for the first time, whether dietary simple sugar intake affects MELD score changes over time in a cohort of cirrhotic liver transplant candidates. (2) Methods: the MELD score, dietary habits using a 3-day food diary, and visceral adipose tissue index (VATI) measured with CT scan were assessed in 80 consecutive outpatient cirrhotic patients at baseline, after counseling to follow current nutritional guidelines. The MELD score was reassessed after six months and the DELTA-MELD was calculated as the MELD at the second assessment minus the MELD at baseline. (3) Results: Compared with the baseline, the MELD score of cirrhotic patients at the end of the study was decreased, stable, or increased in 36%, 8% and 56% of patients, respectively. In separate multiple linear regression models, DELTA-MELD was positively and independently correlated with the daily intake of simple sugars expressed in g/kg body weight (p = 0.01) or as a percentage of total caloric intake (p = 0.0004) and with the number of daily portions of fruit, added sugar, jam, and honey (p = 0.003). These associations were present almost exclusively in patients with VATI above the median value. (4) Conclusions: In cirrhotic patients with high amounts of visceral adipose tissue the consumption of simple sugars and fructose should be limited to improve their clinical outcome. MDPI 2023-03-24 /pmc/articles/PMC10097197/ /pubmed/37049416 http://dx.doi.org/10.3390/nu15071575 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parisse, Simona
Carnevale, Sara
Di Bartolomeo, Francesca
Poli, Edoardo
Miceli, Francesca
Ferri, Flaminia
Mischitelli, Monica
Rocco, Bianca
Lai, Quirino
Lucatelli, Pierleone
Corona, Mario
Mennini, Gianluca
De Santis, Adriano
Rossi, Massimo
Muscaritoli, Maurizio
Cantafora, Alfredo
Ginanni Corradini, Stefano
A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates
title A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates
title_full A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates
title_fullStr A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates
title_full_unstemmed A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates
title_short A Low Daily Intake of Simple Sugars in the Diet Is Associated with Improved Liver Function in Cirrhotic Liver Transplant Candidates
title_sort low daily intake of simple sugars in the diet is associated with improved liver function in cirrhotic liver transplant candidates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097197/
https://www.ncbi.nlm.nih.gov/pubmed/37049416
http://dx.doi.org/10.3390/nu15071575
work_keys_str_mv AT parissesimona alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT carnevalesara alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT dibartolomeofrancesca alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT poliedoardo alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT micelifrancesca alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT ferriflaminia alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT mischitellimonica alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT roccobianca alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT laiquirino alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT lucatellipierleone alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT coronamario alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT menninigianluca alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT desantisadriano alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT rossimassimo alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT muscaritolimaurizio alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT cantaforaalfredo alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT ginannicorradinistefano alowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT parissesimona lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT carnevalesara lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT dibartolomeofrancesca lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT poliedoardo lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT micelifrancesca lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT ferriflaminia lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT mischitellimonica lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT roccobianca lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT laiquirino lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT lucatellipierleone lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT coronamario lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT menninigianluca lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT desantisadriano lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT rossimassimo lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT muscaritolimaurizio lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT cantaforaalfredo lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates
AT ginannicorradinistefano lowdailyintakeofsimplesugarsinthedietisassociatedwithimprovedliverfunctionincirrhoticlivertransplantcandidates