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Frequency of COVID-19 Infection as a Function of Vitamin D Levels

Background: It has been speculated that higher concentrations of 25-hydroxy-vitamin D (25OHD) provide some protection against COVID-19. We assessed whether there is any relationship between 25OHD concentrations and the subsequent development of COVID-19 infection. Materials and Methods: Concentratio...

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Autores principales: Basińska-Lewandowska, Magdalena, Lewandowski, Krzysztof, Horzelski, Wojciech, Lewiński, Andrzej, Skowrońska-Jóźwiak, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097275/
https://www.ncbi.nlm.nih.gov/pubmed/37049423
http://dx.doi.org/10.3390/nu15071581
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author Basińska-Lewandowska, Magdalena
Lewandowski, Krzysztof
Horzelski, Wojciech
Lewiński, Andrzej
Skowrońska-Jóźwiak, Elżbieta
author_facet Basińska-Lewandowska, Magdalena
Lewandowski, Krzysztof
Horzelski, Wojciech
Lewiński, Andrzej
Skowrońska-Jóźwiak, Elżbieta
author_sort Basińska-Lewandowska, Magdalena
collection PubMed
description Background: It has been speculated that higher concentrations of 25-hydroxy-vitamin D (25OHD) provide some protection against COVID-19. We assessed whether there is any relationship between 25OHD concentrations and the subsequent development of COVID-19 infection. Materials and Methods: Concentrations of 25OHD were measured in March–April 2020 in 134 healthy subjects (57 males), age range 6–50, from a single urban general practice in central Poland. Data on COVID-19 infection during the subsequent 12 months (prior to the vaccination program) were obtained from the national database of COVID-19 cases. None of the subjects received any 25OHD supplements. Results: The average 25OHD concentrations were 18.1 ± 7.39 ng/mL (37.3% had 25OHD above 20 ng/mL). Thirty-one (23.1%) patients developed COVID-19 infection, but an increased risk was only observed in individuals with 25OHD concentrations below 12 ng/mL (COVID-19 infection in 11 out of 25 patients (44%) with 25OHD < 12 ng/mL versus 20 out of 109 (18.3%) for those with 25OHD above 12 ng/mL, p = 0.0063). Such a relationship was no longer observed for subjects with 25OHD concentrations above 20 ng/mL (p = 0.2787). Conclusions: Although only a minority of healthy subjects had 25OHD concentrations above 20 ng/mL in spring, an increased risk of subsequent COVID-19 infection was only observed in those with severe 25OHD deficiency (<12 ng/mL).
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spelling pubmed-100972752023-04-13 Frequency of COVID-19 Infection as a Function of Vitamin D Levels Basińska-Lewandowska, Magdalena Lewandowski, Krzysztof Horzelski, Wojciech Lewiński, Andrzej Skowrońska-Jóźwiak, Elżbieta Nutrients Communication Background: It has been speculated that higher concentrations of 25-hydroxy-vitamin D (25OHD) provide some protection against COVID-19. We assessed whether there is any relationship between 25OHD concentrations and the subsequent development of COVID-19 infection. Materials and Methods: Concentrations of 25OHD were measured in March–April 2020 in 134 healthy subjects (57 males), age range 6–50, from a single urban general practice in central Poland. Data on COVID-19 infection during the subsequent 12 months (prior to the vaccination program) were obtained from the national database of COVID-19 cases. None of the subjects received any 25OHD supplements. Results: The average 25OHD concentrations were 18.1 ± 7.39 ng/mL (37.3% had 25OHD above 20 ng/mL). Thirty-one (23.1%) patients developed COVID-19 infection, but an increased risk was only observed in individuals with 25OHD concentrations below 12 ng/mL (COVID-19 infection in 11 out of 25 patients (44%) with 25OHD < 12 ng/mL versus 20 out of 109 (18.3%) for those with 25OHD above 12 ng/mL, p = 0.0063). Such a relationship was no longer observed for subjects with 25OHD concentrations above 20 ng/mL (p = 0.2787). Conclusions: Although only a minority of healthy subjects had 25OHD concentrations above 20 ng/mL in spring, an increased risk of subsequent COVID-19 infection was only observed in those with severe 25OHD deficiency (<12 ng/mL). MDPI 2023-03-24 /pmc/articles/PMC10097275/ /pubmed/37049423 http://dx.doi.org/10.3390/nu15071581 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Basińska-Lewandowska, Magdalena
Lewandowski, Krzysztof
Horzelski, Wojciech
Lewiński, Andrzej
Skowrońska-Jóźwiak, Elżbieta
Frequency of COVID-19 Infection as a Function of Vitamin D Levels
title Frequency of COVID-19 Infection as a Function of Vitamin D Levels
title_full Frequency of COVID-19 Infection as a Function of Vitamin D Levels
title_fullStr Frequency of COVID-19 Infection as a Function of Vitamin D Levels
title_full_unstemmed Frequency of COVID-19 Infection as a Function of Vitamin D Levels
title_short Frequency of COVID-19 Infection as a Function of Vitamin D Levels
title_sort frequency of covid-19 infection as a function of vitamin d levels
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097275/
https://www.ncbi.nlm.nih.gov/pubmed/37049423
http://dx.doi.org/10.3390/nu15071581
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