Cargando…

A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies

Previous cohort studies have reported conflicting associations between alcohol consumption and chronic kidney disease, characterized by proteinuria and low glomerular filtration rate (GFR). This systematic review, which included 14,634,940 participants from 11 cohort studies, assessed a dose-depende...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamamoto, Ryohei, Li, Qinyan, Otsuki, Naoko, Shinzawa, Maki, Yamaguchi, Makoto, Wakasugi, Minako, Nagasawa, Yasuyuki, Isaka, Yoshitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097279/
https://www.ncbi.nlm.nih.gov/pubmed/37049433
http://dx.doi.org/10.3390/nu15071592
_version_ 1785024542304894976
author Yamamoto, Ryohei
Li, Qinyan
Otsuki, Naoko
Shinzawa, Maki
Yamaguchi, Makoto
Wakasugi, Minako
Nagasawa, Yasuyuki
Isaka, Yoshitaka
author_facet Yamamoto, Ryohei
Li, Qinyan
Otsuki, Naoko
Shinzawa, Maki
Yamaguchi, Makoto
Wakasugi, Minako
Nagasawa, Yasuyuki
Isaka, Yoshitaka
author_sort Yamamoto, Ryohei
collection PubMed
description Previous cohort studies have reported conflicting associations between alcohol consumption and chronic kidney disease, characterized by proteinuria and low glomerular filtration rate (GFR). This systematic review, which included 14,634,940 participants from 11 cohort studies, assessed a dose-dependent association of alcohol consumption and incidence of proteinuria and low estimated GFR (eGFR) of <60 mL/min/1.73 m(2). Compared with non-drinkers, the incidence of proteinuria was lower in drinkers with alcohol consumption of ≤12.0 g/day (relative risk 0.87 [95% confidence interval 0.83, 0.92]), but higher in drinkers with alcohol consumption of 36.1–60.0 g/day (1.09 [1.03, 1.15]), suggesting a J-shaped association between alcohol consumption and the incidence of proteinuria. Incidence of low eGFR was lower in drinkers with alcohol consumption of ≤12.0 and 12.1–36.0 than in non-drinkers (≤12.0, 12.1–36.0, and 36.1–60.0 g/day: 0.93 [0.90, 0.95], 0.82 [0.78, 0.86], and 0.89 [0.77, 1.03], respectively), suggesting that drinkers were at lower risk of low eGFR. In conclusion, compared with non-drinkers, mild drinkers were at lower risk of proteinuria and low eGFR, whereas heavy drinkers had a higher risk of proteinuria but a lower risk of low eGFR. The clinical impact of high alcohol consumption should be assessed in well-designed studies.
format Online
Article
Text
id pubmed-10097279
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100972792023-04-13 A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies Yamamoto, Ryohei Li, Qinyan Otsuki, Naoko Shinzawa, Maki Yamaguchi, Makoto Wakasugi, Minako Nagasawa, Yasuyuki Isaka, Yoshitaka Nutrients Systematic Review Previous cohort studies have reported conflicting associations between alcohol consumption and chronic kidney disease, characterized by proteinuria and low glomerular filtration rate (GFR). This systematic review, which included 14,634,940 participants from 11 cohort studies, assessed a dose-dependent association of alcohol consumption and incidence of proteinuria and low estimated GFR (eGFR) of <60 mL/min/1.73 m(2). Compared with non-drinkers, the incidence of proteinuria was lower in drinkers with alcohol consumption of ≤12.0 g/day (relative risk 0.87 [95% confidence interval 0.83, 0.92]), but higher in drinkers with alcohol consumption of 36.1–60.0 g/day (1.09 [1.03, 1.15]), suggesting a J-shaped association between alcohol consumption and the incidence of proteinuria. Incidence of low eGFR was lower in drinkers with alcohol consumption of ≤12.0 and 12.1–36.0 than in non-drinkers (≤12.0, 12.1–36.0, and 36.1–60.0 g/day: 0.93 [0.90, 0.95], 0.82 [0.78, 0.86], and 0.89 [0.77, 1.03], respectively), suggesting that drinkers were at lower risk of low eGFR. In conclusion, compared with non-drinkers, mild drinkers were at lower risk of proteinuria and low eGFR, whereas heavy drinkers had a higher risk of proteinuria but a lower risk of low eGFR. The clinical impact of high alcohol consumption should be assessed in well-designed studies. MDPI 2023-03-25 /pmc/articles/PMC10097279/ /pubmed/37049433 http://dx.doi.org/10.3390/nu15071592 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Yamamoto, Ryohei
Li, Qinyan
Otsuki, Naoko
Shinzawa, Maki
Yamaguchi, Makoto
Wakasugi, Minako
Nagasawa, Yasuyuki
Isaka, Yoshitaka
A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies
title A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies
title_full A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies
title_fullStr A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies
title_full_unstemmed A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies
title_short A Dose-Dependent Association between Alcohol Consumption and Incidence of Proteinuria and Low Glomerular Filtration Rate: A Systematic Review and Meta-Analysis of Cohort Studies
title_sort dose-dependent association between alcohol consumption and incidence of proteinuria and low glomerular filtration rate: a systematic review and meta-analysis of cohort studies
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097279/
https://www.ncbi.nlm.nih.gov/pubmed/37049433
http://dx.doi.org/10.3390/nu15071592
work_keys_str_mv AT yamamotoryohei adosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT liqinyan adosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT otsukinaoko adosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT shinzawamaki adosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT yamaguchimakoto adosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT wakasugiminako adosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT nagasawayasuyuki adosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT isakayoshitaka adosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT yamamotoryohei dosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT liqinyan dosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT otsukinaoko dosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT shinzawamaki dosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT yamaguchimakoto dosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT wakasugiminako dosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT nagasawayasuyuki dosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies
AT isakayoshitaka dosedependentassociationbetweenalcoholconsumptionandincidenceofproteinuriaandlowglomerularfiltrationrateasystematicreviewandmetaanalysisofcohortstudies