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Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions

This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before t...

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Autores principales: Godinho-Mota, Jordana Carolina Marques, Vaz-Gonçalves, Larissa, Dias Custódio, Isis Danyelle, Schroeder de Souza, Jaqueline, Mota, João Felipe, Gonzalez, Maria Cristina, Rodrigues Vilella, Priscylla, Anusca Martins, Karine, de Paiva Maia, Yara Cristina, Verde, Sara Maria Moreira Lima, Frenzel, Aline Porciúncula, Di Pietro, Patricia Faria, da Costa Marinho, Eduarda, Freitas-Junior, Ruffo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097367/
https://www.ncbi.nlm.nih.gov/pubmed/37049529
http://dx.doi.org/10.3390/nu15071689
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author Godinho-Mota, Jordana Carolina Marques
Vaz-Gonçalves, Larissa
Dias Custódio, Isis Danyelle
Schroeder de Souza, Jaqueline
Mota, João Felipe
Gonzalez, Maria Cristina
Rodrigues Vilella, Priscylla
Anusca Martins, Karine
de Paiva Maia, Yara Cristina
Verde, Sara Maria Moreira Lima
Frenzel, Aline Porciúncula
Di Pietro, Patricia Faria
da Costa Marinho, Eduarda
Freitas-Junior, Ruffo
author_facet Godinho-Mota, Jordana Carolina Marques
Vaz-Gonçalves, Larissa
Dias Custódio, Isis Danyelle
Schroeder de Souza, Jaqueline
Mota, João Felipe
Gonzalez, Maria Cristina
Rodrigues Vilella, Priscylla
Anusca Martins, Karine
de Paiva Maia, Yara Cristina
Verde, Sara Maria Moreira Lima
Frenzel, Aline Porciúncula
Di Pietro, Patricia Faria
da Costa Marinho, Eduarda
Freitas-Junior, Ruffo
author_sort Godinho-Mota, Jordana Carolina Marques
collection PubMed
description This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before the infusion of the first cycle of CT (pre-CT), and until two weeks after CT completion (post-CT), regarding body weight, body mass index (BMI); waist circumference (WC); waist-to-height ratio (WHtR); conicity index (C-index); fat mass index (FMI); and fat-free mass index (FFMI). CT regimens were classified as anthracycline-based (AC—doxorubicin or epirubicin); anthracyclines and taxane (ACT); cyclophosphamide, methotrexate, and 5-fluorouracil (CMF); or isolated taxanes (paclitaxel or docetaxel). Women significantly increased BMI and FMI post-CT (p < 0.001 and p = 0.007, respectively). The ACT regimen increased FMI (p < 0.001), while FFMI increased after AC (p = 0.007). It is concluded that the CT negatively impacted body composition and the type of regime had a strong influence. The ACT regimen promoted an increase in FMI compared to other regimens, and the AC increased FFMI. These findings reinforce the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment.
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spelling pubmed-100973672023-04-13 Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions Godinho-Mota, Jordana Carolina Marques Vaz-Gonçalves, Larissa Dias Custódio, Isis Danyelle Schroeder de Souza, Jaqueline Mota, João Felipe Gonzalez, Maria Cristina Rodrigues Vilella, Priscylla Anusca Martins, Karine de Paiva Maia, Yara Cristina Verde, Sara Maria Moreira Lima Frenzel, Aline Porciúncula Di Pietro, Patricia Faria da Costa Marinho, Eduarda Freitas-Junior, Ruffo Nutrients Article This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before the infusion of the first cycle of CT (pre-CT), and until two weeks after CT completion (post-CT), regarding body weight, body mass index (BMI); waist circumference (WC); waist-to-height ratio (WHtR); conicity index (C-index); fat mass index (FMI); and fat-free mass index (FFMI). CT regimens were classified as anthracycline-based (AC—doxorubicin or epirubicin); anthracyclines and taxane (ACT); cyclophosphamide, methotrexate, and 5-fluorouracil (CMF); or isolated taxanes (paclitaxel or docetaxel). Women significantly increased BMI and FMI post-CT (p < 0.001 and p = 0.007, respectively). The ACT regimen increased FMI (p < 0.001), while FFMI increased after AC (p = 0.007). It is concluded that the CT negatively impacted body composition and the type of regime had a strong influence. The ACT regimen promoted an increase in FMI compared to other regimens, and the AC increased FFMI. These findings reinforce the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment. MDPI 2023-03-30 /pmc/articles/PMC10097367/ /pubmed/37049529 http://dx.doi.org/10.3390/nu15071689 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Godinho-Mota, Jordana Carolina Marques
Vaz-Gonçalves, Larissa
Dias Custódio, Isis Danyelle
Schroeder de Souza, Jaqueline
Mota, João Felipe
Gonzalez, Maria Cristina
Rodrigues Vilella, Priscylla
Anusca Martins, Karine
de Paiva Maia, Yara Cristina
Verde, Sara Maria Moreira Lima
Frenzel, Aline Porciúncula
Di Pietro, Patricia Faria
da Costa Marinho, Eduarda
Freitas-Junior, Ruffo
Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions
title Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions
title_full Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions
title_fullStr Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions
title_full_unstemmed Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions
title_short Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions
title_sort impact of chemotherapy regimens on body composition of breast cancer women: a multicenter study across four brazilian regions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097367/
https://www.ncbi.nlm.nih.gov/pubmed/37049529
http://dx.doi.org/10.3390/nu15071689
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