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Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions
This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before t...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097367/ https://www.ncbi.nlm.nih.gov/pubmed/37049529 http://dx.doi.org/10.3390/nu15071689 |
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author | Godinho-Mota, Jordana Carolina Marques Vaz-Gonçalves, Larissa Dias Custódio, Isis Danyelle Schroeder de Souza, Jaqueline Mota, João Felipe Gonzalez, Maria Cristina Rodrigues Vilella, Priscylla Anusca Martins, Karine de Paiva Maia, Yara Cristina Verde, Sara Maria Moreira Lima Frenzel, Aline Porciúncula Di Pietro, Patricia Faria da Costa Marinho, Eduarda Freitas-Junior, Ruffo |
author_facet | Godinho-Mota, Jordana Carolina Marques Vaz-Gonçalves, Larissa Dias Custódio, Isis Danyelle Schroeder de Souza, Jaqueline Mota, João Felipe Gonzalez, Maria Cristina Rodrigues Vilella, Priscylla Anusca Martins, Karine de Paiva Maia, Yara Cristina Verde, Sara Maria Moreira Lima Frenzel, Aline Porciúncula Di Pietro, Patricia Faria da Costa Marinho, Eduarda Freitas-Junior, Ruffo |
author_sort | Godinho-Mota, Jordana Carolina Marques |
collection | PubMed |
description | This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before the infusion of the first cycle of CT (pre-CT), and until two weeks after CT completion (post-CT), regarding body weight, body mass index (BMI); waist circumference (WC); waist-to-height ratio (WHtR); conicity index (C-index); fat mass index (FMI); and fat-free mass index (FFMI). CT regimens were classified as anthracycline-based (AC—doxorubicin or epirubicin); anthracyclines and taxane (ACT); cyclophosphamide, methotrexate, and 5-fluorouracil (CMF); or isolated taxanes (paclitaxel or docetaxel). Women significantly increased BMI and FMI post-CT (p < 0.001 and p = 0.007, respectively). The ACT regimen increased FMI (p < 0.001), while FFMI increased after AC (p = 0.007). It is concluded that the CT negatively impacted body composition and the type of regime had a strong influence. The ACT regimen promoted an increase in FMI compared to other regimens, and the AC increased FFMI. These findings reinforce the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment. |
format | Online Article Text |
id | pubmed-10097367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100973672023-04-13 Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions Godinho-Mota, Jordana Carolina Marques Vaz-Gonçalves, Larissa Dias Custódio, Isis Danyelle Schroeder de Souza, Jaqueline Mota, João Felipe Gonzalez, Maria Cristina Rodrigues Vilella, Priscylla Anusca Martins, Karine de Paiva Maia, Yara Cristina Verde, Sara Maria Moreira Lima Frenzel, Aline Porciúncula Di Pietro, Patricia Faria da Costa Marinho, Eduarda Freitas-Junior, Ruffo Nutrients Article This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before the infusion of the first cycle of CT (pre-CT), and until two weeks after CT completion (post-CT), regarding body weight, body mass index (BMI); waist circumference (WC); waist-to-height ratio (WHtR); conicity index (C-index); fat mass index (FMI); and fat-free mass index (FFMI). CT regimens were classified as anthracycline-based (AC—doxorubicin or epirubicin); anthracyclines and taxane (ACT); cyclophosphamide, methotrexate, and 5-fluorouracil (CMF); or isolated taxanes (paclitaxel or docetaxel). Women significantly increased BMI and FMI post-CT (p < 0.001 and p = 0.007, respectively). The ACT regimen increased FMI (p < 0.001), while FFMI increased after AC (p = 0.007). It is concluded that the CT negatively impacted body composition and the type of regime had a strong influence. The ACT regimen promoted an increase in FMI compared to other regimens, and the AC increased FFMI. These findings reinforce the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment. MDPI 2023-03-30 /pmc/articles/PMC10097367/ /pubmed/37049529 http://dx.doi.org/10.3390/nu15071689 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Godinho-Mota, Jordana Carolina Marques Vaz-Gonçalves, Larissa Dias Custódio, Isis Danyelle Schroeder de Souza, Jaqueline Mota, João Felipe Gonzalez, Maria Cristina Rodrigues Vilella, Priscylla Anusca Martins, Karine de Paiva Maia, Yara Cristina Verde, Sara Maria Moreira Lima Frenzel, Aline Porciúncula Di Pietro, Patricia Faria da Costa Marinho, Eduarda Freitas-Junior, Ruffo Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
title | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
title_full | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
title_fullStr | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
title_full_unstemmed | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
title_short | Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions |
title_sort | impact of chemotherapy regimens on body composition of breast cancer women: a multicenter study across four brazilian regions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097367/ https://www.ncbi.nlm.nih.gov/pubmed/37049529 http://dx.doi.org/10.3390/nu15071689 |
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