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Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097417/ https://www.ncbi.nlm.nih.gov/pubmed/37043266 http://dx.doi.org/10.7554/eLife.82925 |
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author | Zarzor, Mohammad Saeed Blumcke, Ingmar Budday, Silvia |
author_facet | Zarzor, Mohammad Saeed Blumcke, Ingmar Budday, Silvia |
author_sort | Zarzor, Mohammad Saeed |
collection | PubMed |
description | The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mechanical forces at the macroscale remains insufficiently understood. Recent findings suggest that an additional proliferating zone, the outer subventricular zone (OSVZ), is decisive for the particular size and complexity of the human cortex. To better understand how the OSVZ affects cortical folding, we establish a multifield computational model that couples cell proliferation in different zones and migration at the cell scale with growth and cortical folding at the organ scale by combining an advection-diffusion model with the theory of finite growth. We validate our model based on data from histologically stained sections of the human fetal brain and predict 3D pattern formation. Finally, we address open questions regarding the role of the OSVZ for the formation of cortical folds. The presented framework not only improves our understanding of human brain development, but could eventually help diagnose and treat neuronal disorders arising from disruptions in cellular development and associated malformations of cortical development. |
format | Online Article Text |
id | pubmed-10097417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-100974172023-04-13 Exploring the role of the outer subventricular zone during cortical folding through a physics-based model Zarzor, Mohammad Saeed Blumcke, Ingmar Budday, Silvia eLife Neuroscience The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mechanical forces at the macroscale remains insufficiently understood. Recent findings suggest that an additional proliferating zone, the outer subventricular zone (OSVZ), is decisive for the particular size and complexity of the human cortex. To better understand how the OSVZ affects cortical folding, we establish a multifield computational model that couples cell proliferation in different zones and migration at the cell scale with growth and cortical folding at the organ scale by combining an advection-diffusion model with the theory of finite growth. We validate our model based on data from histologically stained sections of the human fetal brain and predict 3D pattern formation. Finally, we address open questions regarding the role of the OSVZ for the formation of cortical folds. The presented framework not only improves our understanding of human brain development, but could eventually help diagnose and treat neuronal disorders arising from disruptions in cellular development and associated malformations of cortical development. eLife Sciences Publications, Ltd 2023-04-12 /pmc/articles/PMC10097417/ /pubmed/37043266 http://dx.doi.org/10.7554/eLife.82925 Text en © 2023, Zarzor et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Zarzor, Mohammad Saeed Blumcke, Ingmar Budday, Silvia Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
title | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
title_full | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
title_fullStr | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
title_full_unstemmed | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
title_short | Exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
title_sort | exploring the role of the outer subventricular zone during cortical folding through a physics-based model |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097417/ https://www.ncbi.nlm.nih.gov/pubmed/37043266 http://dx.doi.org/10.7554/eLife.82925 |
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