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Exploring the role of the outer subventricular zone during cortical folding through a physics-based model

The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mec...

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Detalles Bibliográficos
Autores principales: Zarzor, Mohammad Saeed, Blumcke, Ingmar, Budday, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097417/
https://www.ncbi.nlm.nih.gov/pubmed/37043266
http://dx.doi.org/10.7554/eLife.82925
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author Zarzor, Mohammad Saeed
Blumcke, Ingmar
Budday, Silvia
author_facet Zarzor, Mohammad Saeed
Blumcke, Ingmar
Budday, Silvia
author_sort Zarzor, Mohammad Saeed
collection PubMed
description The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mechanical forces at the macroscale remains insufficiently understood. Recent findings suggest that an additional proliferating zone, the outer subventricular zone (OSVZ), is decisive for the particular size and complexity of the human cortex. To better understand how the OSVZ affects cortical folding, we establish a multifield computational model that couples cell proliferation in different zones and migration at the cell scale with growth and cortical folding at the organ scale by combining an advection-diffusion model with the theory of finite growth. We validate our model based on data from histologically stained sections of the human fetal brain and predict 3D pattern formation. Finally, we address open questions regarding the role of the OSVZ for the formation of cortical folds. The presented framework not only improves our understanding of human brain development, but could eventually help diagnose and treat neuronal disorders arising from disruptions in cellular development and associated malformations of cortical development.
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spelling pubmed-100974172023-04-13 Exploring the role of the outer subventricular zone during cortical folding through a physics-based model Zarzor, Mohammad Saeed Blumcke, Ingmar Budday, Silvia eLife Neuroscience The human brain has a highly complex structure both on the microscopic and on the macroscopic scales. Increasing evidence has suggested the role of mechanical forces for cortical folding – a classical hallmark of the human brain. However, the link between cellular processes at the microscale and mechanical forces at the macroscale remains insufficiently understood. Recent findings suggest that an additional proliferating zone, the outer subventricular zone (OSVZ), is decisive for the particular size and complexity of the human cortex. To better understand how the OSVZ affects cortical folding, we establish a multifield computational model that couples cell proliferation in different zones and migration at the cell scale with growth and cortical folding at the organ scale by combining an advection-diffusion model with the theory of finite growth. We validate our model based on data from histologically stained sections of the human fetal brain and predict 3D pattern formation. Finally, we address open questions regarding the role of the OSVZ for the formation of cortical folds. The presented framework not only improves our understanding of human brain development, but could eventually help diagnose and treat neuronal disorders arising from disruptions in cellular development and associated malformations of cortical development. eLife Sciences Publications, Ltd 2023-04-12 /pmc/articles/PMC10097417/ /pubmed/37043266 http://dx.doi.org/10.7554/eLife.82925 Text en © 2023, Zarzor et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Zarzor, Mohammad Saeed
Blumcke, Ingmar
Budday, Silvia
Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
title Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
title_full Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
title_fullStr Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
title_full_unstemmed Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
title_short Exploring the role of the outer subventricular zone during cortical folding through a physics-based model
title_sort exploring the role of the outer subventricular zone during cortical folding through a physics-based model
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097417/
https://www.ncbi.nlm.nih.gov/pubmed/37043266
http://dx.doi.org/10.7554/eLife.82925
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