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Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy

Nanophotothermal agents that provide efficient and precise treatment at tumor sites are attracting increasing attention in biomedicine. In particular, the method combination of nanophotothermal agents and magnetic resonance imaging (MRI) shows great promise for biomedical therapeutic applications. H...

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Autores principales: Du, Liang, Chen, Wei, Zhong, Jie, Yan, Shuang, Yang, Chenwu, Pu, Yu, Zhu, Jiang, Chen, Tianwu, Zhang, Xiaoming, Wu, Changqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097457/
https://www.ncbi.nlm.nih.gov/pubmed/37066094
http://dx.doi.org/10.1093/rb/rbad022
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author Du, Liang
Chen, Wei
Zhong, Jie
Yan, Shuang
Yang, Chenwu
Pu, Yu
Zhu, Jiang
Chen, Tianwu
Zhang, Xiaoming
Wu, Changqiang
author_facet Du, Liang
Chen, Wei
Zhong, Jie
Yan, Shuang
Yang, Chenwu
Pu, Yu
Zhu, Jiang
Chen, Tianwu
Zhang, Xiaoming
Wu, Changqiang
author_sort Du, Liang
collection PubMed
description Nanophotothermal agents that provide efficient and precise treatment at tumor sites are attracting increasing attention in biomedicine. In particular, the method combination of nanophotothermal agents and magnetic resonance imaging (MRI) shows great promise for biomedical therapeutic applications. Herein, a simple nanophotothermal agent with dopamine multivalent-modified polyaspartic acid chelated superparamagnetic iron oxide (SPIO) and ferric ion (SPIO@PAsp-DAFe/PEG) was developed for MRI-guided near-infrared photothermal therapy (PTT). SPIO@PAsp-DAFe/PEG was random SPIO nanocluster with good water solubility, had a diameter of 57.8 ± 7.8 nm in dynamic light scattering, negatively charged surface (zeta potential = −11 mV), exhibited good stability and outstanding photothermal conversion efficiency (35.4%) and produced superior magnetic resonance enhanced imaging. In the experiment with tumor-bearing mice, the MRI not only monitored the accumulation of SPIO@PAsp-DAFe/PEG nanocomposites enhanced by near-infrared irradiation after intravenous administration but also determined the appropriate time window for PTT. With the use of MRI-guided near-infrared therapy, the SPIO@PAsp-DAFe/PEG nanocomposites provided excellent therapeutic effects, confirming their great potential as effective MRI/PTT therapeutic agents.
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spelling pubmed-100974572023-04-13 Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy Du, Liang Chen, Wei Zhong, Jie Yan, Shuang Yang, Chenwu Pu, Yu Zhu, Jiang Chen, Tianwu Zhang, Xiaoming Wu, Changqiang Regen Biomater Research Article Nanophotothermal agents that provide efficient and precise treatment at tumor sites are attracting increasing attention in biomedicine. In particular, the method combination of nanophotothermal agents and magnetic resonance imaging (MRI) shows great promise for biomedical therapeutic applications. Herein, a simple nanophotothermal agent with dopamine multivalent-modified polyaspartic acid chelated superparamagnetic iron oxide (SPIO) and ferric ion (SPIO@PAsp-DAFe/PEG) was developed for MRI-guided near-infrared photothermal therapy (PTT). SPIO@PAsp-DAFe/PEG was random SPIO nanocluster with good water solubility, had a diameter of 57.8 ± 7.8 nm in dynamic light scattering, negatively charged surface (zeta potential = −11 mV), exhibited good stability and outstanding photothermal conversion efficiency (35.4%) and produced superior magnetic resonance enhanced imaging. In the experiment with tumor-bearing mice, the MRI not only monitored the accumulation of SPIO@PAsp-DAFe/PEG nanocomposites enhanced by near-infrared irradiation after intravenous administration but also determined the appropriate time window for PTT. With the use of MRI-guided near-infrared therapy, the SPIO@PAsp-DAFe/PEG nanocomposites provided excellent therapeutic effects, confirming their great potential as effective MRI/PTT therapeutic agents. Oxford University Press 2023-03-14 /pmc/articles/PMC10097457/ /pubmed/37066094 http://dx.doi.org/10.1093/rb/rbad022 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Du, Liang
Chen, Wei
Zhong, Jie
Yan, Shuang
Yang, Chenwu
Pu, Yu
Zhu, Jiang
Chen, Tianwu
Zhang, Xiaoming
Wu, Changqiang
Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy
title Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy
title_full Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy
title_fullStr Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy
title_full_unstemmed Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy
title_short Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy
title_sort dopamine multivalent-modified polyaspartic acid for mri-guided near-infrared photothermal therapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097457/
https://www.ncbi.nlm.nih.gov/pubmed/37066094
http://dx.doi.org/10.1093/rb/rbad022
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