Cargando…

Exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in Nigeria

Previous epidemiological studies demonstrated an increased risk of respiratory health effects in children and adults exposed to dampness or mold. This study investigated associations of quantitative indicators of indoor dampness and mold exposure with severe lower respiratory tract infections (LRTI)...

Descripción completa

Detalles Bibliográficos
Autores principales: Fakunle, Adekunle Gregory, Jafta, Nkosana, Okekunle, Akinkunmi Paul, Smit, Lidwien A. M, Naidoo, Rajen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097558/
https://www.ncbi.nlm.nih.gov/pubmed/37064421
http://dx.doi.org/10.1097/EE9.0000000000000247
_version_ 1785024599989157888
author Fakunle, Adekunle Gregory
Jafta, Nkosana
Okekunle, Akinkunmi Paul
Smit, Lidwien A. M
Naidoo, Rajen N.
author_facet Fakunle, Adekunle Gregory
Jafta, Nkosana
Okekunle, Akinkunmi Paul
Smit, Lidwien A. M
Naidoo, Rajen N.
author_sort Fakunle, Adekunle Gregory
collection PubMed
description Previous epidemiological studies demonstrated an increased risk of respiratory health effects in children and adults exposed to dampness or mold. This study investigated associations of quantitative indicators of indoor dampness and mold exposure with severe lower respiratory tract infections (LRTI) among children aged 1–59 months in Ibadan, Nigeria. METHODS: In-home visits were conducted among 178 children hospitalized with LRTI matched by age (±3 months), sex, and geographical location with 180 community-based children without LRTI. Trained study staff evaluated the indoor environment using a standardized home walkthrough checklist and measured visible dampness and mold damage. Damp-moldy Index (DMI) was also estimated to quantify the level of exposure. Exposure-response relationships of dampness and mold exposure with severe LRTI were assessed using multivariable restricted cubic spline regression models adjusting for relevant child, housing, and environmental characteristics. RESULTS: Severe LRTI cases were more often male than female (61.8%), and the overall mean (SD) age was 7.3 (1.35) months. Children exposed to dampness <0.3 m(2) (odds ratio [OR] = 2.11; 95% confidence interval [CI] = 1.05, 4.36), and between 0.3 and 1.0 m(2) (OR = 2.34; 95% CI = 1.01, 7.32), had a higher odds of severe LRTI compared with children not exposed to dampness. The restricted cubic spline showed a linear exposure-response association between severe LRTI and residential dampness (P < 0.001) but a nonlinear relationship with DMI (P = 0.01). CONCLUSIONS: Residential dampness and DMI were exposure-dependently associated with higher odds of severe LRTI among under-five children. If observed relationships were causal, public health intervention strategies targeted at reducing residential dampness are critically important to mitigate the burden of severe LRTI among under-five children.
format Online
Article
Text
id pubmed-10097558
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-100975582023-04-13 Exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in Nigeria Fakunle, Adekunle Gregory Jafta, Nkosana Okekunle, Akinkunmi Paul Smit, Lidwien A. M Naidoo, Rajen N. Environ Epidemiol Original Research Article Previous epidemiological studies demonstrated an increased risk of respiratory health effects in children and adults exposed to dampness or mold. This study investigated associations of quantitative indicators of indoor dampness and mold exposure with severe lower respiratory tract infections (LRTI) among children aged 1–59 months in Ibadan, Nigeria. METHODS: In-home visits were conducted among 178 children hospitalized with LRTI matched by age (±3 months), sex, and geographical location with 180 community-based children without LRTI. Trained study staff evaluated the indoor environment using a standardized home walkthrough checklist and measured visible dampness and mold damage. Damp-moldy Index (DMI) was also estimated to quantify the level of exposure. Exposure-response relationships of dampness and mold exposure with severe LRTI were assessed using multivariable restricted cubic spline regression models adjusting for relevant child, housing, and environmental characteristics. RESULTS: Severe LRTI cases were more often male than female (61.8%), and the overall mean (SD) age was 7.3 (1.35) months. Children exposed to dampness <0.3 m(2) (odds ratio [OR] = 2.11; 95% confidence interval [CI] = 1.05, 4.36), and between 0.3 and 1.0 m(2) (OR = 2.34; 95% CI = 1.01, 7.32), had a higher odds of severe LRTI compared with children not exposed to dampness. The restricted cubic spline showed a linear exposure-response association between severe LRTI and residential dampness (P < 0.001) but a nonlinear relationship with DMI (P = 0.01). CONCLUSIONS: Residential dampness and DMI were exposure-dependently associated with higher odds of severe LRTI among under-five children. If observed relationships were causal, public health intervention strategies targeted at reducing residential dampness are critically important to mitigate the burden of severe LRTI among under-five children. Lippincott Williams & Wilkins 2023-03-29 /pmc/articles/PMC10097558/ /pubmed/37064421 http://dx.doi.org/10.1097/EE9.0000000000000247 Text en Copyright © 2023 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Research Article
Fakunle, Adekunle Gregory
Jafta, Nkosana
Okekunle, Akinkunmi Paul
Smit, Lidwien A. M
Naidoo, Rajen N.
Exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in Nigeria
title Exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in Nigeria
title_full Exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in Nigeria
title_fullStr Exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in Nigeria
title_full_unstemmed Exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in Nigeria
title_short Exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in Nigeria
title_sort exposure-response relationship of residential dampness and mold damage with severe lower respiratory tract infections among under-five children in nigeria
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097558/
https://www.ncbi.nlm.nih.gov/pubmed/37064421
http://dx.doi.org/10.1097/EE9.0000000000000247
work_keys_str_mv AT fakunleadekunlegregory exposureresponserelationshipofresidentialdampnessandmolddamagewithseverelowerrespiratorytractinfectionsamongunderfivechildreninnigeria
AT jaftankosana exposureresponserelationshipofresidentialdampnessandmolddamagewithseverelowerrespiratorytractinfectionsamongunderfivechildreninnigeria
AT okekunleakinkunmipaul exposureresponserelationshipofresidentialdampnessandmolddamagewithseverelowerrespiratorytractinfectionsamongunderfivechildreninnigeria
AT smitlidwienam exposureresponserelationshipofresidentialdampnessandmolddamagewithseverelowerrespiratorytractinfectionsamongunderfivechildreninnigeria
AT naidoorajenn exposureresponserelationshipofresidentialdampnessandmolddamagewithseverelowerrespiratorytractinfectionsamongunderfivechildreninnigeria