Cryo-EM structure of the transposon-associated TnpB enzyme

The class 2 type V CRISPR effector Cas12 is thought to have evolved from the IS200/IS605 superfamily of transposon-associated TnpB proteins(1). Recent studies have identified TnpB proteins as miniature RNA-guided DNA endonucleases(2,3). TnpB associates with a single, long RNA (ωRNA) and cleaves doub...

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Detalles Bibliográficos
Autores principales: Nakagawa, Ryoya, Hirano, Hisato, Omura, Satoshi N., Nety, Suchita, Kannan, Soumya, Altae-Tran, Han, Yao, Xiao, Sakaguchi, Yuriko, Ohira, Takayuki, Wu, Wen Y., Nakayama, Hiroshi, Shuto, Yutaro, Tanaka, Tatsuki, Sano, Fumiya K., Kusakizako, Tsukasa, Kise, Yoshiaki, Itoh, Yuzuru, Dohmae, Naoshi, van der Oost, John, Suzuki, Tsutomu, Zhang, Feng, Nureki, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097598/
https://www.ncbi.nlm.nih.gov/pubmed/37020030
http://dx.doi.org/10.1038/s41586-023-05933-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097598/
https://www.ncbi.nlm.nih.gov/pubmed/37020030
http://dx.doi.org/10.1038/s41586-023-05933-9

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