Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence

cGAS is an evolutionarily conserved enzyme that has a pivotal role in immune defence against infection(1–3). In vertebrate animals, cGAS is activated by DNA to produce cyclic GMP–AMP (cGAMP)(4,5), which leads to the expression of antimicrobial genes(6,7). In bacteria, cyclic dinucleotide (CDN)-based...

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Detalles Bibliográficos
Autores principales: Jenson, Justin M., Li, Tuo, Du, Fenghe, Ea, Chee-Kwee, Chen, Zhijian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097602/
https://www.ncbi.nlm.nih.gov/pubmed/36848932
http://dx.doi.org/10.1038/s41586-023-05862-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097602/
https://www.ncbi.nlm.nih.gov/pubmed/36848932
http://dx.doi.org/10.1038/s41586-023-05862-7

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