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Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence
cGAS is an evolutionarily conserved enzyme that has a pivotal role in immune defence against infection(1–3). In vertebrate animals, cGAS is activated by DNA to produce cyclic GMP–AMP (cGAMP)(4,5), which leads to the expression of antimicrobial genes(6,7). In bacteria, cyclic dinucleotide (CDN)-based...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097602/ https://www.ncbi.nlm.nih.gov/pubmed/36848932 http://dx.doi.org/10.1038/s41586-023-05862-7 |