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LRP6 High Bone Mass Characterized in Two Generations Harboring a Unique Mutation of Low‐Density Lipoprotein Receptor‐Related Protein 6

Osteoblast Wnt/β‐catenin signaling conditions skeletal development and health. Bone formation is stimulated when on the osteoblast surface a Wnt binds to low‐density lipoprotein receptor‐related protein 5 (LRP5) or 6 (LRP6), in turn coupled to a frizzled receptor. Sclerostin and dickkopf1 inhibit os...

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Detalles Bibliográficos
Autores principales:	Whyte, Michael P, Mumm, Steven, Baker, Jonathan C, Zhang, Fan, Sedighi, Homer, Duan, Shenghui, Cundy, Tim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10097642/ https://www.ncbi.nlm.nih.gov/pubmed/37065631 http://dx.doi.org/10.1002/jbm4.10717

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